Blake E G Collins, Brett A Gordon, Daniel W T Wundersitz, David Carey, Michael I C Kingsley
{"title":"The Dose-Response Relationship of Aerobic Exercise on Cardiorespiratory Fitness in Cardiac Rehabilitation: A SYSTEMATIC REVIEW AND META-ANALYSIS.","authors":"Blake E G Collins, Brett A Gordon, Daniel W T Wundersitz, David Carey, Michael I C Kingsley","doi":"10.1097/HCR.0000000000000963","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the incremental dose-response effect of aerobic exercise-based cardiac rehabilitation programs (ExCRP) on cardiorespiratory fitness in comparison to non-exercise controls among people with coronary heart disease (CHD).</p><p><strong>Review methods: </strong>Medline, CINAHL, Cochrane, SCOPUS, and SPORTDiscus were searched from January 1, 2000 until December 4, 2023. Articles were eligible for selection if they satisfied the following criteria: randomized controlled studies assessing change in cardiorespiratory fitness among people with CHD in non-exercise and aerobic intervention groups, established peak oxygen uptake via cardiopulmonary exercise test, minimum of 4-week program duration, and reported frequency, intensity, and duration of prescribed exercise. The study was prospectively registered (PROSPERO ID: CRD42021274924).</p><p><strong>Summary: </strong>Thirty-three studies, including 1901 participants were included in the continuous dose-analysis. A significant difference in cardiorespiratory fitness was identified between ExCRP and non-exercise control that favored exercise by 3.4 (3.0-3.9) mL·kg -1 ·min -1 . No difference existed between interval and continuous training when matched for exercise dose. Dose-response analyses identified a significant increase in cardiorespiratory fitness (3.4 [2.9-5.5] mL·kg -1 ·min -1 ) associated with program completion, with no additional benefit related to increased exercise dose. When compared to non-exercise control, participating in ExCRP with a minimum total program intervention dose of 2194 metabolic equivalent minutes significantly improves cardiorespiratory fitness. However, no additional benefit was discernible from higher exercise doses. Although the recommended dose for ExCRP augments medical treatment and is sufficient to improve cardiorespiratory fitness, it is likely that the narrow range in prescribed exercise dose and variations in the fidelity of exercise interventions limit interpretation.</p>","PeriodicalId":15192,"journal":{"name":"Journal of Cardiopulmonary Rehabilitation and Prevention","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiopulmonary Rehabilitation and Prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HCR.0000000000000963","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To explore the incremental dose-response effect of aerobic exercise-based cardiac rehabilitation programs (ExCRP) on cardiorespiratory fitness in comparison to non-exercise controls among people with coronary heart disease (CHD).
Review methods: Medline, CINAHL, Cochrane, SCOPUS, and SPORTDiscus were searched from January 1, 2000 until December 4, 2023. Articles were eligible for selection if they satisfied the following criteria: randomized controlled studies assessing change in cardiorespiratory fitness among people with CHD in non-exercise and aerobic intervention groups, established peak oxygen uptake via cardiopulmonary exercise test, minimum of 4-week program duration, and reported frequency, intensity, and duration of prescribed exercise. The study was prospectively registered (PROSPERO ID: CRD42021274924).
Summary: Thirty-three studies, including 1901 participants were included in the continuous dose-analysis. A significant difference in cardiorespiratory fitness was identified between ExCRP and non-exercise control that favored exercise by 3.4 (3.0-3.9) mL·kg -1 ·min -1 . No difference existed between interval and continuous training when matched for exercise dose. Dose-response analyses identified a significant increase in cardiorespiratory fitness (3.4 [2.9-5.5] mL·kg -1 ·min -1 ) associated with program completion, with no additional benefit related to increased exercise dose. When compared to non-exercise control, participating in ExCRP with a minimum total program intervention dose of 2194 metabolic equivalent minutes significantly improves cardiorespiratory fitness. However, no additional benefit was discernible from higher exercise doses. Although the recommended dose for ExCRP augments medical treatment and is sufficient to improve cardiorespiratory fitness, it is likely that the narrow range in prescribed exercise dose and variations in the fidelity of exercise interventions limit interpretation.
期刊介绍:
JCRP was the first, and remains the only, professional journal dedicated to improving multidisciplinary clinical practice and expanding research evidence specific to both cardiovascular and pulmonary rehabilitation. This includes exercise testing and prescription, behavioral medicine, and cardiopulmonary risk factor management. In 2007, JCRP expanded its scope to include primary prevention of cardiovascular and pulmonary diseases. JCRP publishes scientific and clinical peer-reviewed Original Investigations, Reviews, and Brief or Case Reports focused on the causes, prevention, and treatment of individuals with cardiovascular or pulmonary diseases in both a print and online-only format. Editorial features include Editorials, Invited Commentaries, Literature Updates, and Clinically-relevant Topical Updates. JCRP is the official Journal of the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation.