Evaluation of the efficacy and safety of durvalumab combined with chemotherapy, radiotherapy, or other agents in advanced non-small cell lung cancer: a meta-analysis.
{"title":"Evaluation of the efficacy and safety of durvalumab combined with chemotherapy, radiotherapy, or other agents in advanced non-small cell lung cancer: a meta-analysis.","authors":"Min Xu, Ran Cui, Xinlin Yu","doi":"10.62347/BNVX1803","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Durvalumab may improve survival in patients with advanced non-small cell lung cancer (NSCLC) when given as maintenance therapy; nevertheless, further research is required. Durvalumab and other drugs have enhanced survival rates in advanced NSCLC. The optimal therapy combination is uncertain. This trial will evaluate the effectiveness and tolerability of Durvalumab-based combination therapy for advanced NSCLC.</p><p><strong>Methods: </strong>We searched PubMed, Embase, the Cochrane Library, and Web of Science for relevant papers, obtaining information on overall response rate (ORR), median progression-free survival (mPFS), median overall survival (mOS), and adverse events (AEs).</p><p><strong>Results: </strong>13 studies were included that involved a total of 2,277 participants. The ORR of Durvalumab combination therapy in NSCLC was 41.6%, rising to 47.1% within the radiation or chemotherapy cohort. The mPFS was 5.1 months, while the mOS was 13.5 months. The 1-year progression-free survival (PFS) rate was 49.0%, while the 2-year overall survival (OS) rate was 42.9%. In the radiation and chemotherapy subgroups, these rates rose to 53.4% and 61.1%, respectively. The prevalent adverse responses were anemia (31.3%), nausea (18.9%), and fatigue (18.6%).</p><p><strong>Conclusions: </strong>Our meta-analysis demonstrated that Durvalumab combination treatment is both effective and safe for advanced NSCLC, particularly in patients undergoing combined chemoradiotherapy. These results encourage more Phase III studies. The review agreement is recorded on PROSPERO (CRD42024622471) and is on the NIHR HTA program website.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 6","pages":"203-221"},"PeriodicalIF":0.9000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238800/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of clinical and experimental pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62347/BNVX1803","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Durvalumab may improve survival in patients with advanced non-small cell lung cancer (NSCLC) when given as maintenance therapy; nevertheless, further research is required. Durvalumab and other drugs have enhanced survival rates in advanced NSCLC. The optimal therapy combination is uncertain. This trial will evaluate the effectiveness and tolerability of Durvalumab-based combination therapy for advanced NSCLC.
Methods: We searched PubMed, Embase, the Cochrane Library, and Web of Science for relevant papers, obtaining information on overall response rate (ORR), median progression-free survival (mPFS), median overall survival (mOS), and adverse events (AEs).
Results: 13 studies were included that involved a total of 2,277 participants. The ORR of Durvalumab combination therapy in NSCLC was 41.6%, rising to 47.1% within the radiation or chemotherapy cohort. The mPFS was 5.1 months, while the mOS was 13.5 months. The 1-year progression-free survival (PFS) rate was 49.0%, while the 2-year overall survival (OS) rate was 42.9%. In the radiation and chemotherapy subgroups, these rates rose to 53.4% and 61.1%, respectively. The prevalent adverse responses were anemia (31.3%), nausea (18.9%), and fatigue (18.6%).
Conclusions: Our meta-analysis demonstrated that Durvalumab combination treatment is both effective and safe for advanced NSCLC, particularly in patients undergoing combined chemoradiotherapy. These results encourage more Phase III studies. The review agreement is recorded on PROSPERO (CRD42024622471) and is on the NIHR HTA program website.
期刊介绍：
The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
