Altered glucose metabolism in default mode network and prefrontal circuit in patients with Kallmann syndrome.

IF 3.1 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Research Pub Date : 2025-07-11 DOI:10.1186/s13550-025-01282-y

Chunqing Zhou, Xueying Wang, Meichao Men, Xiaoping Yi, Ke Cao, Weidan Pu, Marcus Hacker, Xiang Li, Min Zhao

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引用次数: 0

Abstract

Background: This study delineates brain metabolic signatures underlying neuroendocrine-psychosocial interactions in Kallmann syndrome (KS), a rare genetic disorder characterized by congenital hypogonadism and anosmia. In this prospective case-control study, 30 KS patients and 30 matched healthy controls (HCs) underwent brain [¹⁸F]FDG PET scans, sex hormone assays, and standardized neuropsychological assessments. A voxel-wise group comparison analysis was conducted to identify clusters of brain metabolic patterns between KS patients and HCs. Subsequently, correlation and mediation analyses were performed to investigate the interrelationships and mediating effect among brain metabolic patterns, sex hormone levels, and psychosocial factors.

Results: We identified six hypermetabolic clusters in KS patients, predominantly located in the fronto-limbic system and the default mode network (DMN) in KS patients. These clusters of hypermetabolism were significantly associated fertility anxiety scale (FAS), health information avoidance scale (HIAS) and health information overload scale (HIOS). In addition, mediation analysis indicated that bilateral basal ganglia hypermetabolism acted as a significant mediator between HIAS and FAS (β = 0.274, P = 0.031).

Conclusion: Patients with KS exhibited a distinct hypermetabolism pattern in the DMN-prefrontal circuit, which functionally bridges neuroendocrine dysfunction and reproductive health anxiety.

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Kallmann综合征患者默认模式网络和前额叶回路中糖代谢的改变。

背景：本研究描述了Kallmann综合征（KS）神经内分泌-社会心理相互作用的脑代谢特征，Kallmann综合征是一种罕见的遗传疾病，以先天性性腺功能减退和嗅觉缺失为特征。在这项前瞻性病例对照研究中，30名KS患者和30名匹配的健康对照（hc）接受了脑部[18F]FDG PET扫描、性激素检测和标准化神经心理学评估。进行了体素组比较分析，以确定KS患者和hc患者之间的脑代谢模式簇。随后，进行了相关分析和中介分析，探讨脑代谢模式、性激素水平和社会心理因素之间的相互关系和中介作用。结果：我们在KS患者中发现了6个高代谢簇，主要位于KS患者的额边缘系统和默认模式网络（DMN）。这些高代谢集群与生育焦虑量表（FAS）、健康信息回避量表（HIAS）和健康信息超载量表（HIOS）显著相关。此外，双侧基底节区高代谢在HIAS和FAS之间起着重要的中介作用（β = 0.274, P = 0.031）。结论：KS患者在dmn -前额叶回路中表现出明显的高代谢模式，该回路在功能上连接神经内分泌功能障碍和生殖健康焦虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-

CiteScore

5.90

自引率

3.10%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.