The Role of Estrogen in Mitochondrial Disease.

IF 3.6 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2025-07-11 DOI:10.1007/s10571-025-01592-8

Xi Huang, Cun-Hui Pan, Fei Yin, Jing Peng, Li Yang

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引用次数: 0

Abstract

This review aims to investigate the potential role of estrogen in various mitochondrial diseases, such as Leber's Hereditary Optic Neuropathy and Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes, focusing on its effects on aging, oxidative stress, mitochondrial biogenesis, and mitophagy. Mitochondrial diseases have become important in modern medical research due to their complex genetic background and diverse clinical manifestations. Studies in recent years have shown that estrogen plays an essential role in physiological regulation and may also affect the health status of cells by regulating mitochondrial function, which in turn affects the occurrence and development of diseases. However, there is still a lack of systematic review of estrogen's specific mechanisms and roles in these diseases. This review will synthesize the relevant literature to explore the association between estrogen and mitochondrial diseases and its possible therapeutic prospects, aiming to provide a theoretical basis and reference for future research.

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雌激素在线粒体疾病中的作用。

本文旨在探讨雌激素在各种线粒体疾病中的潜在作用，如Leber遗传性视神经病变和线粒体脑肌病、乳酸酸中毒和卒中样发作，重点关注其对衰老、氧化应激、线粒体生物发生和线粒体自噬的影响。线粒体疾病因其复杂的遗传背景和多样的临床表现，在现代医学研究中占有重要地位。近年来的研究表明，雌激素在生理调节中起着至关重要的作用，也可能通过调节线粒体功能影响细胞的健康状态，进而影响疾病的发生和发展。然而，雌激素在这些疾病中的具体机制和作用仍缺乏系统的综述。本文将综合相关文献，探讨雌激素与线粒体疾病的关系及其可能的治疗前景，旨在为今后的研究提供理论基础和参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.