Cryoneurolysis: Parallel Growth in PubMed Publications and Google Trends Analysis Reveals Exponential Interest.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CardioVascular and Interventional Radiology Pub Date : 2025-07-10 DOI:10.1007/s00270-025-04118-3

Francois H Cornelis, Rozan Bokhari, Ruben Geevarghese, Dimitrios K Filippiadis

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引用次数: 0

Abstract

Purpose: This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.

Materials and methods: Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword "cryoneurolysis." Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.

Results: Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3-4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8-50.4) in 2025 to 72.6 (95% CI: 59.2-86.0) by 2030.

Conclusion: Analysis reveals parallel academic-public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.

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冷冻神经溶解：在PubMed出版物和谷歌趋势分析中平行增长揭示了指数兴趣。

目的：本研究分析了全球对冷冻神经松解术（一种用于非阿片类疼痛治疗的微创神经消融技术）的兴趣，确定了影响采用的时间趋势、地理分布和商业驱动因素。材料和方法：回顾性分析谷歌Trends数据（2004年1月-2025年3月）和PubMed出版物（1993年-2025年），使用关键词“cryyoneurolysis”。统计分析包括Mann-Kendall趋势检验、Portmanteau白噪声检验、Dickey-Fuller单位根检验和Spearman相关性。预测采用非季节性霍尔特-温特斯平滑和局部多项式回归。结果：从2004年到2019年中期，搜索兴趣仍然可以忽略不计（SVI = 0），学术活动比公众兴趣早3-4年。两个数据集都显示出显著的上升趋势（PubMed: τ = 0.80, p）。结论：分析显示，商业因素、发达国家的地理集中以及介入放射学的新兴应用推动了学术和公共利益的平行增长，表明到2030年将得到更广泛的采用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CardioVascular and Interventional Radiology 医学-核医学

CiteScore

5.50

自引率

13.80%

发文量

306

审稿时长

3-8 weeks

期刊介绍： CardioVascular and Interventional Radiology (CVIR) is the official journal of the Cardiovascular and Interventional Radiological Society of Europe, and is also the official organ of a number of additional distinguished national and international interventional radiological societies. CVIR publishes double blinded peer-reviewed original research work including clinical and laboratory investigations, technical notes, case reports, works in progress, and letters to the editor, as well as review articles, pictorial essays, editorials, and special invited submissions in the field of vascular and interventional radiology. Beside the communication of the latest research results in this field, it is also the aim of CVIR to support continuous medical education. Articles that are accepted for publication are done so with the understanding that they, or their substantive contents, have not been and will not be submitted to any other publication.