Enhanced Recovery After Surgery Programs Safely Accelerate Recovery in Emergency Abdominal Surgery: A Randomized Controlled Trial With Multivariable Risk Profiling.
Jianing Lu, Yan Zhuang, Zhenglu Wang, Hong Zheng, Xi Ma, Dejun Kong, Jinliang Duan, Shaofeng Chen, Tao Chen
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引用次数: 0
Abstract
Background: Emergency abdominal surgery involves complex, diverse conditions with high patient variability, posing recovery challenges. While Enhanced Recovery After Surgery (ERAS) programs benefit elective surgery and show promise in emergencies, current research is disease-specific, limiting broad assessment. This study evaluates ERAS safety/effectiveness across multiple emergency abdominal conditions and identifies recovery risk factors.
Methods: This single-blind trial randomized 305 emergency abdominal surgery patients to ERAS (n = 151) or conventional care (n = 154). ERAS patients underwent perioperative enhanced recovery programs, while controls received conventional management. The primary outcome was time to postoperative recovery criteria. Secondary outcomes included first postoperative flatus/semi-liquid diet tolerance time, complication rates, maximum pain scores (days 1-5), 30-day readmissions, and satisfaction. Data were analyzed via t-tests, Mann-Whitney U, Fisher's exact tests, and multivariate regression (p < 0.05 significance).
Results: ERAS reduced median recovery time (141 h [IQR: 114-179] vs. 163 h [IQR: 131-204], p < 0.001), accelerated gastrointestinal recovery (first flatus: 1.10 vs. 1.30 days; semi-liquid tolerance: 3.60 vs. 4.10 days, both p < 0.05), and improved satisfaction (95 vs. 91, p < 0.001). No differences in complications (11.9% vs. 15.6%, p = 0.353) or 30-day readmissions (2.0% vs. 2.6%, p > 0.999). Shock index and APACHE II were common risk factors; ERAS-specific risks included SOFA (OR = 1.31, 1.03-1.71, p = 0.034), preoperative hemoglobin (OR = 0.95, 0.89-1.00, p = 0.046), preparation time (OR = 0.33, 0.14-0.68, p = 0.005), and blood transfusion (OR = 0.01, 0.00-0.23, p = 0.003).
Conclusion: ERAS enhances postoperative recovery and satisfaction in emergency abdominal surgery without increasing complications/readmissions. Identified risk factors support personalized protocols, advancing ERAS implementation.
期刊介绍：
ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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