Mixture risk assessment approaches to evaluate oral exposure to PFAS: Outputs and recommendations of an expert workshop

IF 3.5 4区医学 Q1 MEDICINE, LEGAL

Regulatory Toxicology and Pharmacology Pub Date : 2025-07-08 DOI:10.1016/j.yrtph.2025.105907

Wieneke Bil, Julia Hartmann, Martine Bakker, Bas Bokkers

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引用次数: 0

Abstract

Per- and polyfluoroalkyl substances (PFAS) often co-occur as contaminants in drinking water and food. Various mixture risk assessment (MRA) approaches have been published to address the associated human health risks.

The Dutch National Institute for Public Health and the Environment (RIVM) organized an online workshop to discuss PFAS MRA approaches. Over 50 experts participated, representing research institutes, universities and government organizations internationally. A discussion document with scientific literature and considerations on PFAS MRA approaches was shared with participants ahead of the workshop.

The workshop yielded overall agreement among participants in support of evidence pointing towards no interaction and dose-additivity of PFAS mixtures. Participants broadly supported the need for a flexible, component-based MRA approach to accommodate the variability in PFAS mixtures and the integration of new PFAS. Overall, the workshop underscored the need to ensure that risk assessments are both scientifically robust and practically feasible, and showed that the global mixture risk assessment community is largely in agreement regarding evaluation of PFAS.

The input received as well as the outcomes of this workshop were used by RIVM in a recommendation to the World Health Organisation (WHO) on suitable approaches for assessment of PFAS in food and drinking water.

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评估口服PFAS暴露的混合风险评估方法：专家研讨会的产出和建议

全氟烷基和多氟烷基物质（PFAS）经常作为污染物共存于饮用水和食品中。已经发布了各种混合风险评估方法，以处理相关的人类健康风险。荷兰国家公共卫生与环境研究所（RIVM）组织了一次在线讲习班，讨论PFAS MRA方法。50多名专家参加了会议，他们代表了国际上的研究机构、大学和政府组织。在研讨会之前，与与会者分享了一份讨论文件，其中包括关于PFAS MRA方法的科学文献和考虑。研讨会在与会者之间达成了总体共识，支持证据指向无相互作用和剂量加和性的PFAS混合物。与会者广泛支持需要一种灵活的、基于组件的MRA方法，以适应PFAS混合物的可变性和新PFAS的集成。总的来说，讲习班强调了确保风险评估既科学可靠又实际可行的必要性，并表明全球混合风险评估界在评估PFAS方面基本上是一致的。在向世界卫生组织（世卫组织）提出的关于评估食品和饮用水中全氟磺酸钠的适当方法的建议中，利用了该讲习班收到的投入和成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Toxicology and Pharmacology 医学-毒理学

CiteScore

6.70

自引率

8.80%

发文量

147

审稿时长

58 days

期刊介绍： Regulatory Toxicology and Pharmacology publishes peer reviewed articles that involve the generation, evaluation, and interpretation of experimental animal and human data that are of direct importance and relevance for regulatory authorities with respect to toxicological and pharmacological regulations in society. All peer-reviewed articles that are published should be devoted to improve the protection of human health and environment. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of toxicological and pharmacological compounds on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of human and environmental health. Types of peer-reviewed articles published: -Original research articles of relevance for regulatory aspects covering aspects including, but not limited to: 1.Factors influencing human sensitivity 2.Exposure science related to risk assessment 3.Alternative toxicological test methods 4.Frameworks for evaluation and integration of data in regulatory evaluations 5.Harmonization across regulatory agencies 6.Read-across methods and evaluations -Contemporary Reviews on policy related Research issues -Letters to the Editor -Guest Editorials (by Invitation)