Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis.

Diabetes Pub Date : 2025-09-01 DOI:10.2337/db24-0931

Clive H Wasserfall, Chris E Forsmark, Shuang Li, Liang Li, Phil A Hart, Mark O Goodarzi, Yogish C Kudva, Melena D Bellin, Dhiraj Yadav, Darwin L Conwell, Jose Serrano, Dana K Andersen, William Fisher, Anna Casu, Ken Cusi, Steven J Hughes, Evan Fogel, Walter Park, Stephen K Van Den Eeden

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Abstract

Article highlights: Type 1 diabetes-associated autoimmune mechanisms have not been thoroughly examined in pancreatitis-associated diabetes. We assessed the prevalence of four islet autoantibodies in serum from a large prospective cohort of patients with acute, recurrent acute, or chronic pancreatitis. Diabetes was present in 11 (12%) of 94 participants with acute pancreatitis, 69 (27%) of 273 with recurrent acute pancreatitis, and 235 (43%) of 560 with chronic pancreatitis. Excluding those with only insulin autoantibody positivity, which is confounded by insulin treatment, islet autoantibodies were identified in 51 (5.5%) of 927 participants, and 30 (3.2%) of 297 were positive for two or more autoantibodies. Our findings suggest pancreatitis may elicit islet autoimmunity in a subset of patients, necessitating prospective longitudinal follow-up.

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1型糖尿病自身抗体在急性，复发急性和慢性胰腺炎。

1型糖尿病相关的自身免疫机制尚未在胰腺炎相关糖尿病中得到彻底的研究。我们评估了急性、复发性急性或慢性胰腺炎患者血清中四种胰岛自身抗体的患病率。94例急性胰腺炎患者中有11例（12%）存在糖尿病，273例复发性急性胰腺炎患者中有69例（27%）存在糖尿病，560例慢性胰腺炎患者中有235例（43%）存在糖尿病。排除仅胰岛素自身抗体阳性（与胰岛素治疗混淆）的参与者，927名参与者中有51人（5.5%）检测到胰岛自身抗体，297名参与者中有30人（3.2%）检测到两种或两种以上自身抗体阳性。我们的研究结果表明，胰腺炎可能在一部分患者中引起胰岛自身免疫，需要前瞻性的纵向随访。

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Diabetes

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