Study of abortion material in idiopathic habitual miscarriage of pregnancy: Literature review.

Abstract

Objective: Aim: The study aims to review current scientific publications on the genetic study of foetal material in habitual miscarriage with an emphasis on a comparative analysis of the methods used traditional karyotyping and chromosomal microarray analysis. The material in this paper is based on an analysis of scientific publications covering the issues under study over the past five years.

Patients and methods: Materials and Methods: This study reviewed cytogenetic diagnostic methods for detecting genetic abnormalities in foetal material from recurrent miscarriages. A comparative analysis of the widely used methods, karyotyping and chromosomal microarray analysis (CMA), was conducted to assess their strengths and limitations.

Conclusion: Conclusions: Given its superior diagnostic capabilities, CMA should be adopted as the first-line method for investigating genetic abnormalities in cases of habitual miscarriage. Its ability to detect a wider range of chromosomal abnormalities allows for more accurate diagnosis and better-informed clinical decisions. The use of CMA in routine practice can significantly improve the management of future pregnancies, offering couples a greater chance of successful outcomes and providing reproductive health specialists with a more reliable tool for evaluating repeated pregnancy loss.