High mobility group box 1 as a biomarker for lumbar disc herniation severity in chronic low back pain.

Q3 Medicine

International Journal of Critical Illness and Injury Science Pub Date : 2025-04-01 Epub Date: 2025-06-23 DOI:10.4103/ijciis.ijciis_1_25

Rosa Dwi Wahyuni, Dachruddin Ngatimin, M Sabir, Adhar Arifuddin, A Fahira Nur, Abd Farid Lewa

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引用次数: 0

Abstract

Introduction: Chronic low back pain (LBP) is a widespread condition that significantly affects daily life. High mobility group box 1 (HMGB1), a proinflammatory cytokine, may contribute to the pathophysiology of LBP, particularly in relation to nucleus pulposus herniation (NHP). This study aimed to examine the correlation between herniation severity and lumbosacral HMGB1 levels in chronic LBP patients.

Methods: This analytical observational study with a cross-sectional design was conducted in 2023 at Anutapura General Hospital, Palu. A total of 64 chronic LBP patients participated. Serum HMGB1 levels were measured, and magnetic resonance imaging was used to assess herniation severity. Pain severity was evaluated using the Numeric Pain Rating Scale (NPRS).

Results: The mean HMGB1 level was 4701 (±1001.88). LBP onset was most common between 4 and 12 months (mean duration: 11.52 ± 5.54 months), with pain more frequently located on the right side (59%). Grade 3 herniation occurred most often (59%), and moderate pain (NPRS score 6) was the most common. HMGB1 levels peaked in Grade 2 herniation (5939.10 ± 873.26). NPRS scores increased with herniation severity, but weak correlations were found between NHP and HMGB1 (r = 0.174) and between HMGB1 and NPRS (r = 0.114).

Conclusions: No strong relationship was found between NHP and HMGB1 levels in chronic LBP patients. Further studies are needed to clarify HMGB1's role in LBP pathophysiology and its potential as a biomarker for disease severity or treatment response.

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高活动度组1作为慢性腰痛患者腰椎间盘突出严重程度的生物标志物。

慢性腰痛（LBP）是一种普遍存在的严重影响日常生活的疾病。高迁移率组框1 （HMGB1）是一种促炎细胞因子，可能与腰痛的病理生理有关，特别是与髓核突出（NHP）有关。本研究旨在探讨慢性腰痛患者腰椎间盘突出严重程度与腰骶部HMGB1水平的相关性。方法：本分析性观察研究采用横断面设计，于2023年在帕卢的阿努塔普拉综合医院进行。共有64名慢性腰痛患者参与。测定血清HMGB1水平，并用磁共振成像评估疝的严重程度。使用数字疼痛评定量表（NPRS）评估疼痛严重程度。结果：HMGB1平均水平为4701（±1001.88）。腰痛发病最常见于4 ~ 12个月（平均持续时间：11.52±5.54个月），疼痛多见于右侧（59%）。3级疝最常见（59%），中度疼痛（NPRS评分6分）最常见。HMGB1水平在2级疝中最高（5939.10±873.26）。NPRS评分随疝的严重程度而增加，但NHP与HMGB1之间呈弱相关（r = 0.174）， HMGB1与NPRS之间呈弱相关（r = 0.114）。结论：慢性腰痛患者NHP与HMGB1水平无明显相关性。需要进一步的研究来阐明HMGB1在腰痛病理生理中的作用及其作为疾病严重程度或治疗反应的生物标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Critical Illness and Injury Science Medicine-Emergency Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： IJCIIS encourages research, education and dissemination of knowledge in the field of Critical Illness and Injury Science across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in the emergency intensive care and promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.