Anthropometrics, cancer risks, and survival outcomes in adult patients with glioma - a systematic review and meta-analysis.

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-07-10 DOI:10.1007/s00701-025-06579-4

Jaehyun Ahn, Joonseok Kim, Christopher Shin, Stephen Ahn

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引用次数: 0

Abstract

Purpose: The association between anthropometric measures including BMI, height and cancer has been widely discussed. However, the role of these in the development and prognosis of glioma remains controversial. We aimed to study these relationships.

Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Papers reporting relationship between anthropometric measures and the risk of glioma, both incidence and survival, were considered relevant. Those published until January 31, 2024, were selected from PubMed, EMBASE, and the Cochrane Library. Studies were evaluated according to the modified Newcastle Ottawa Scale. Hazard ratios, relative risks, and 95% confidence intervals were pooled and synthesized using a random effects model.

Results: Among 940 screened articles, 23 were selected. Taller height was significantly associated with an increased risk of both glioma (HR per 10 cm, 1.19; CI, 1.16 to 1.23) and glioblastoma (HR per 10 cm, 1.25; CI, 1.18 to 1.31). Higher BMI was positively correlated with an increased risk of glioma, both in categorical (RR, 1.08; CI, 1.03 to 1.12) and continuous measures (HR per 5 kg/m², 1.01; CI, 1.00 to 1.03). Glioblastoma demonstrated a higher incidence risk (HR per 5 kg/m², 1.02; 95% CI 1.00 to 1.05) and better survival outcomes (HR 0.75; 95% CI 0.59 to 0.96) with increasing BMI.

Conclusion: This study provides critical insights into the relationship between glioma and anthropometric measures. Glioma and glioblastoma were associated with these measures in terms of both incidence and survival. Further research is necessary to uncover the mechanisms and develop preventative or therapeutic strategies.

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成人胶质瘤患者的人体测量学、癌症风险和生存结果——一项系统综述和荟萃分析。

目的：人体测量指标包括BMI、身高与癌症之间的关系已被广泛讨论。然而，这些在胶质瘤的发展和预后中的作用仍然存在争议。我们的目的是研究这些关系。方法：我们遵循系统评价和荟萃分析的首选报告项目（PRISMA）报告指南。报告人体测量值与胶质瘤发病率和生存率之间关系的论文被认为是相关的。截止2024年1月31日发表的论文均选自PubMed、EMBASE和Cochrane图书馆。根据修改后的纽卡斯尔渥太华量表对研究进行评估。使用随机效应模型对风险比、相对风险和95%置信区间进行汇总和综合。结果：940篇筛选文章中筛选出23篇。较高的身高与两种胶质瘤的风险增加显著相关(HR / 10 cm, 1.19；CI， 1.16至1.23)和胶质母细胞瘤(每10厘米HR， 1.25；CI, 1.18 - 1.31)。BMI越高，患胶质瘤的风险越高(RR, 1.08；CI, 1.03 ~ 1.12)和连续测量(HR每5 kg/m2, 1.01；CI, 1.00 ~ 1.03)。胶质母细胞瘤的发病率更高(HR / 5 kg/m2, 1.02；95% CI 1.00 ~ 1.05)和更好的生存结局(HR 0.75；95%可信区间为0.59 ~ 0.96)。结论：这项研究为胶质瘤与人体测量之间的关系提供了重要的见解。胶质瘤和胶质母细胞瘤在发病率和生存率方面与这些指标相关。需要进一步的研究来揭示其机制并制定预防或治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.