17-year trends in radiological disease burden of multiple sclerosis at presentation

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-07-04 DOI:10.1016/j.msard.2025.106607

Millie Taylor , Omar Alrawashdeh , Nikos Evangelou , Afagh Garjani

引用次数: 0

Abstract

At a population level, MS disease progression appears to have slowed in recent years. This study assessed whether earlier detection of people with potentially milder radiological disease is contributing to these observed trends in MS disease course. The time from MS symptom-onset to the initial brain MRI of the study population alongside the white matter lesion count and volume on this scan had not significantly changed over 17 years (2006 – 2023). The age-related MS Severity Score significantly decreased, and the MS Severity Score remained unchanged throughout the study period. These findings suggest that earlier detection of disease or lower radiological disease burden at presentation do not explain improved outcomes in MS.

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多发性硬化症发病时放射学疾病负担17年趋势

在人口水平上，近年来多发性硬化症的进展似乎有所减缓。本研究评估了早期发现潜在轻度放射学疾病的人是否有助于MS病程中观察到的这些趋势。从MS症状发作到研究人群的初始脑MRI时间，以及该扫描的白质病变计数和体积在17年间（2006 - 2023）没有显著变化。与年龄相关的MS严重程度评分显著下降，MS严重程度评分在整个研究期间保持不变。这些发现表明，早期发现疾病或较低的影像学疾病负担并不能解释多发性硬化症预后的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.