Substrate-Controlled Palladium(II)-Catalyzed Regiodivergent Oxypalladation/C-H Annulation of Alkynylaryl Carboxylates with o-Bromobenzoic Acids.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-10 DOI:10.1021/acs.orglett.5c02161

Zhiwei Li,Sen Lei,Jingru Xia,Yanling Zhang,Bing Liu,Yun Liang,Yuan Yang

引用次数: 0

Abstract

Herein, a palladium-catalyzed regiodivergent oxypalladation/C-H annulation for the synthesis of polyarene-fused isocoumarins using different alkynylaryl carboxylate substrates as a controlled switch is reported. When o-alkynylbenzoates are employed to react with o-bromobenzoic acids, tribenzo[c,f,h]chromen-6-ones are synthesized by sequential 6-endo cyclization, C-H activation, and decarboxylative cyclization. Using 8-(alkynyl)-1-naphthoates as the substrates enables the construction of benzo[g]naphthochromen-4-ones via a 6-exo cyclization/C-H activation process.

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底物控制的钯（II）催化烷基芳基羧酸酯与邻溴苯甲酸的区域分散氧泛化/C-H环化。

本文报道了一种钯催化的区域分散氧化/C-H环化方法，该方法使用不同的烷基芳基羧酸盐底物作为控制开关，用于合成聚芳烃融合的异香豆素。邻炔基苯甲酸酯与邻溴苯甲酸反应，通过6-内环、c - h活化和脱羧环化反应，合成了三苯并[c，f,h] -6- 1。以8-（炔基）-1-萘酸酯为底物，通过6-外显子环化/C-H活化过程，构建了苯并[g]萘酚-4- 1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.