N⁶-methyladenosine modification and skin diseases.

Q3 Medicine

中南大学学报(医学版) Pub Date : 2025-03-28 DOI:10.11817/j.issn.1672-7347.2025.240222

Ling Jiang, Yibo Hu, Jing Chen

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引用次数: 0

Abstract

Currently, research on N⁶-methyladenine (m⁶A) is extensive in the field of oncology, while studies involving m⁶A and skin diseases remain relatively limited. Based on existing reports, we searched PubMed and Web of Science for literature related to m⁶A and dermatological conditions. Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m⁶A-related research. Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases, particularly melanoma, psoriasis, and skin development. Transcriptomic data from the Gene Expression Omnibus (GEO) were analyzed, revealing differential expression of m⁶A-related genes in 4 types of skin tumors (including squamous cell carcinoma and basal cell carcinoma) as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis, and potential mechanisms of action were also explored. Findings suggest that m⁶A modifications exhibit heterogeneity between neoplastic and non-neoplastic skin diseases. However, the regulatory mechanisms of m⁶A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.

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n6 -甲基腺苷修饰与皮肤病。

目前，n6 -甲基腺嘌呤（m6A）在肿瘤领域的研究较为广泛，而涉及m6A与皮肤病的研究相对有限。基于已有的报道，我们检索了PubMed和Web of Science中与m6A和皮肤病相关的文献。对引文数量和期刊影响因子的分析显示，m6a相关研究的数量呈显著上升趋势。标题和摘要的词频分析表明，研究主要集中在皮肤肿瘤和炎症或免疫相关的皮肤病，特别是黑色素瘤、牛皮癣和皮肤发育。通过对基因表达图谱（Gene Expression Omnibus， GEO）转录组学数据的分析，发现m6a相关基因在4种皮肤肿瘤（包括鳞状细胞癌和基底细胞癌）以及炎症性皮肤病（如银屑病和特应性皮炎）中的差异表达，并探讨其潜在的作用机制。研究结果表明，m6A修饰在肿瘤性和非肿瘤性皮肤病之间表现出异质性。然而，m6A动态修饰对皮肤疾病相关关键基因的调控机制尚不清楚，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中南大学学报(医学版) Medicine-Medicine (all)

CiteScore

1.00

自引率

0.00%

发文量

8237

期刊介绍： Journal of Central South University (Medical Sciences), founded in 1958, is a comprehensive academic journal of medicine and health sponsored by the Ministry of Education and Central South University. The journal has been included in many important databases and authoritative abstract journals at home and abroad, such as the American Medline, Pubmed and its Index Medicus (IM), the Netherlands Medical Abstracts (EM), the American Chemical Abstracts (CA), the WHO Western Pacific Region Medical Index (WPRIM), and the Chinese Science Citation Database (Core Database) (CSCD); it is a statistical source journal of Chinese scientific and technological papers, a Chinese core journal, and a "double-effect" journal of the Chinese Journal Matrix; it is the "2nd, 3rd, and 4th China University Excellent Science and Technology Journal", "2008 China Excellent Science and Technology Journal", "RCCSE China Authoritative Academic Journal (A+)" and Hunan Province's "Top Ten Science and Technology Journals". The purpose of the journal is to reflect the new achievements, new technologies, and new experiences in medical research, medical treatment, and teaching, report new medical trends at home and abroad, promote academic exchanges, improve academic standards, and promote scientific and technological progress.