Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease.

IF 1.3 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2025-06-26 eCollection Date: 2025-06-01 DOI:10.31083/RCM27140

Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang

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Abstract

Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI. These mechanisms are profoundly complex and involve sodium voltage-gated channel α subunit 5 (SCN5A) and sodium voltage-gated channel α subunit 10 (SCN10A) single nucleotide polymorphisms, aberrant splicing of SCN5A mRNAs, transcriptional and post-transcriptional regulation, translation, post-translational transport, and modification, along with protein degradation. These mechanisms ultimately promote a decrease in peak sodium currents, an increase in late sodium currents, and changes in sodium channel kinetics. This review aimed to explore the specific mechanisms of Nav1.5 in post-MI arrhythmias and summarize the potential of therapeutic drugs. An in-depth study of the effect of Nav1.5 on arrhythmias after myocardial ischemia is of crucial clinical significance.

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电压门控钠通道：缺血性心脏病的治疗靶点。

心肌梗死（MI）相关心律失常是心源性猝死的重要危险因素。心脏电压门控钠通道（Nav1.5）在心肌梗死后室性心律失常的发展中起重要作用，其机制非常复杂，涉及钠电压门控通道α亚基5 （SCN5A）和钠电压门控通道α亚基10 （SCN10A）单核苷酸多态性、SCN5A mrna的异常剪接、转录和转录后调控、翻译、翻译后转运和修饰。伴随着蛋白质的降解。这些机制最终促进了峰值钠电流的减少，后期钠电流的增加，以及钠通道动力学的变化。本文旨在探讨Nav1.5在心肌梗死后心律失常中的具体机制，并总结治疗药物的潜力。深入研究Nav1.5对心肌缺血后心律失常的影响具有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.