Risk assessment of gallbladder cancer in patients with primary sclerosing cholangitis and gallbladder polyps: a systematic review.

IF 1.8 3区医学 Q2 SURGERY

Langenbeck's Archives of Surgery Pub Date : 2025-07-09 DOI:10.1007/s00423-025-03678-9

Ieva Grikyte, Povilas Ignatavicius

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引用次数: 0

Abstract

Purpose: To review, evaluate and summarize data from the literature presenting the risk of developing gallbladder cancer in patients with PSC and gallbladder polyps.

Methods: The systematic review was performed according to PRISMA recommendations and registered in the PROSPERO database. The PubMed, ScienceDirect, Web of Science, Biomed Central and EBSCOhost databases were used. Studies analysing patients with PSC and gallbladder polyps, their association with malignancy and outcomes were included.

Results: Five retrospective studies and one case-control study with a total of 3415 patients diagnosed with PSC were included. Radiological examination of these 3324 patients with PSC revealed 207 (6.2%) gallbladder polyps, of which 34 (16.4%) were identified as gallbladder mass lesions. Of available histology results, 116 (34%) had gallbladder polyps. Out of these 116 patients with gallbladder polyps, gallbladder carcinoma (GBC) was found in 48 (41.4%) patients. The mean size of gallbladder polyps with adenocarcinoma ranged from 2.1 cm to 2.4 cm, whereas benign polyps ranged from 0.6 cm to 1.5 cm.

Conclusion: Gallbladder polyps with malignant changes are often observed in patients diagnosed with PSC. This supports international recommendations that cholecystectomy should be performed regardless of gallbladder polyp's size in PSC patients.

查看原文本刊更多论文

原发性硬化性胆管炎和胆囊息肉患者胆囊癌的风险评估：一项系统综述。

目的：回顾、评价和总结有关PSC合并胆囊息肉患者发生胆囊癌风险的文献资料。方法：根据PRISMA推荐进行系统评价，并在PROSPERO数据库中注册。使用PubMed、ScienceDirect、Web of Science、Biomed Central和EBSCOhost数据库。研究分析了PSC和胆囊息肉患者及其与恶性肿瘤和预后的关系。结果：5项回顾性研究和1项病例对照研究共纳入3415例诊断为PSC的患者。3324例PSC患者的影像学检查显示胆囊息肉207例（6.2%），其中34例（16.4%）为胆囊肿块性病变。在现有的组织学结果中，116例（34%）有胆囊息肉。在116例胆囊息肉患者中，48例（41.4%）患者发现胆囊癌（GBC）。腺癌胆囊息肉的平均大小为2.1 cm至2.4 cm，而良性息肉的平均大小为0.6 cm至1.5 cm。结论：胆囊息肉伴恶性改变常见于PSC患者。这支持了国际上的建议，即无论PSC患者的胆囊息肉大小如何，都应进行胆囊切除术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Langenbeck's Archives of Surgery 医学-外科

CiteScore

3.30

自引率

8.70%

发文量

342

审稿时长

4-8 weeks

期刊介绍： Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.