Impact of Lower-Extremity Muscle Strength on Exercise Capacity in Patients With Cardiovascular Disease and Diabetes Mellitus.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiopulmonary Rehabilitation and Prevention Pub Date : 2025-07-09 DOI:10.1097/HCR.0000000000000962

Koya Takino, Takuji Adachi, Yoji Kuze, Takashi Nagai, Masaya Hori, Masayasu Nakagawa

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Abstract

Purpose: Although skeletal muscle abnormalities caused by diabetes mellitus (DM) suggest that peripheral muscle impairment may have a greater effect on exercise tolerance in patients with DM, the magnitude of this effect on reduced exercise capacity remains unclear. As such, this study aimed to compare the strength of the association between lower-extremity muscle strength and exercise capacity in patients diagnosed with cardiovascular disease (CVD) with and without DM.

Methods: This retrospective cross-sectional study included data from 262 patients divided into two groups: patients with DM (DM group; n = 106); and without DM (non-DM group; n = 156). Peak oxygen uptake (VO2peak) and isometric knee extensor strength (IKES) were measured. Correlations between VO2peak and IKES were analyzed using Pearson's correlation test in the DM and non-DM groups. Linear regression analyses were performed with VO2peak as the dependent variable, and IKES, confounders, and the interaction term DM × IKES as the independent variables. Separate linear regression analyses were performed for the DM and non-DM groups.

Results: The correlation coefficient between VO2peak and IKES was 0.58 in the DM group and 0.26 in the non-DM group. The interaction term DM × IKES had a significant effect on VO2peak. The IKES was significantly associated with VO2peak in the DM group (β = 0.83, P < .001), but not in the non-DM group (β = 0.01, P = .96).

Conclusion: A specific association between lower-extremity muscle strength and VO2peak was observed in patients with both CVD and DM.

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心血管疾病和糖尿病患者下肢肌力对运动能力的影响

目的：虽然糖尿病（DM）引起的骨骼肌异常表明外周肌肉损伤可能对DM患者的运动耐量有更大的影响，但这种影响对运动能力降低的影响程度尚不清楚。因此，本研究旨在比较诊断为心血管疾病（CVD）合并和不合并DM的患者下肢肌肉力量和运动能力之间的相关性。方法：本回顾性横断面研究纳入262例患者的数据，分为两组：DM患者(DM组；N = 106)；无糖尿病组(非糖尿病组；N = 156)。测量峰值摄氧量（VO2peak）和等长膝关节伸肌强度（kes）。采用Pearson相关检验分析DM组和非DM组VO2peak与kes的相关性。以VO2peak为因变量，IKES、混杂因素和交互项DM × IKES为自变量，进行线性回归分析。分别对糖尿病组和非糖尿病组进行线性回归分析。结果：DM组VO2peak与kes的相关系数为0.58，非DM组为0.26。交互作用项DM × kes对vo2峰有显著影响。糖尿病组IKES与VO2peak有显著相关性（β = 0.83, P < 0.001），非糖尿病组IKES与VO2peak无显著相关性（β = 0.01, P = 0.96）。结论：在心血管疾病和糖尿病患者中，下肢肌肉力量和VO2peak之间存在特定的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiopulmonary Rehabilitation and Prevention 医学-心血管系统

CiteScore

5.40

自引率

34.20%

发文量

164

审稿时长

6-12 weeks

期刊介绍： JCRP was the first, and remains the only, professional journal dedicated to improving multidisciplinary clinical practice and expanding research evidence specific to both cardiovascular and pulmonary rehabilitation. This includes exercise testing and prescription, behavioral medicine, and cardiopulmonary risk factor management. In 2007, JCRP expanded its scope to include primary prevention of cardiovascular and pulmonary diseases. JCRP publishes scientific and clinical peer-reviewed Original Investigations, Reviews, and Brief or Case Reports focused on the causes, prevention, and treatment of individuals with cardiovascular or pulmonary diseases in both a print and online-only format. Editorial features include Editorials, Invited Commentaries, Literature Updates, and Clinically-relevant Topical Updates. JCRP is the official Journal of the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation.