{"title":"Sexual identity inequalities in the co-occurrence of poor mental health and health risk behaviours-a national cross-sectional study.","authors":"Amal R Khanolkar, Alexis Karamanos, Laia Becares","doi":"10.1186/s12916-025-04236-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mental health problems (MHP, like depression/anxiety) and health and risk behaviours (HRBs) are more common among sexual minority adolescents (SMA) than in heterosexual peers. Limited studies have examined the co-occurrence of poor mental health and HRBs, if co-occurrence differs by sexual identity, and associated risks for self-harm and attempted suicide in adolescents.</p><p><strong>Methods: </strong>This study included 10,233 adolescents aged 17 years (51% female/11% sexual minority) from the UK-wide Millennium Cohort Study. Sexual identity, MHP, seven HRBs (like regular smoking, drug use and sexual risk behaviour), self-harm and attempted suicide were self-reported. MHP were assessed using the strengths and difficulties questionnaire [SDQ] emotional symptoms subscale for depression/anxiety. We assessed associations between sexual identity and co-occurrence of MHP and HRBs using multinomial logistic regression. We estimated predicted probabilities for self-harm or attempted suicide based on sexual identity and MHP-HRB co-occurrence status using logistic regression models with appropriate interaction terms (between sexual identity and MHP-HRB co-occurrence status variables).</p><p><strong>Results: </strong>MHP prevalence was higher in gay/lesbian (48%) and bisexual (49%) adolescents compared to heterosexual peers (19%). Self-harm (bisexual, 64%; gay/lesbian, 53%; heterosexual, 19%) and attempted suicide (bisexual, 24%; gay/lesbian, 17%; heterosexual, 6%) prevalence were higher in SMA compared to heterosexual peers. Gay/lesbian and bisexual adolescents consistently had higher probability for MHP-HRB co-occurrence compared to heterosexual peers (example, for gay/lesbian individuals: RRR 3.16 [95% CI 2.1-4.68] for MHP-1HRB, RRR 3.54 [95% CI 2.06-6.08] for MHP- ≥ 3HRB, for bisexual adolescents: RRR 2.44 [95% CI 1.85-3.20] for MHP-1HRB, RRR 4.11 [95% CI 2.99-5.66] for MHP- ≥ 3HRB). MHP-HRB co-occurrence and sexual minority identity were independently associated with greater odds for self-harm or attempted suicide. SMA had higher probabilities of reporting self-harm than heterosexual peers with the same level of MHP-HRB co-occurrence. For example, 37.2% of heterosexual adolescents with MHP-1HRB reported self-harm. Corresponding numbers were twice as high in bisexual (75.7%) and gay/lesbian (77.9%) individuals. Similarly, 58.3% of heterosexual adolescents with MHP- ≥ 3HRBs reported self-harm, increasing to 84.6% in bisexual and 83.8% in gay/lesbian peers.</p><p><strong>Conclusions: </strong>SMA are more likely to experience MHP-HRB co-occurrence, which is associated with substantially higher risks for self-harm and attempted suicide compared to heterosexual peers. Findings highlight the need for better public health policies to address MHP and associated comorbidities to reduce sexual identity-related health inequities in adolescence.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"417"},"PeriodicalIF":7.0000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239281/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12916-025-04236-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Mental health problems (MHP, like depression/anxiety) and health and risk behaviours (HRBs) are more common among sexual minority adolescents (SMA) than in heterosexual peers. Limited studies have examined the co-occurrence of poor mental health and HRBs, if co-occurrence differs by sexual identity, and associated risks for self-harm and attempted suicide in adolescents.
Methods: This study included 10,233 adolescents aged 17 years (51% female/11% sexual minority) from the UK-wide Millennium Cohort Study. Sexual identity, MHP, seven HRBs (like regular smoking, drug use and sexual risk behaviour), self-harm and attempted suicide were self-reported. MHP were assessed using the strengths and difficulties questionnaire [SDQ] emotional symptoms subscale for depression/anxiety. We assessed associations between sexual identity and co-occurrence of MHP and HRBs using multinomial logistic regression. We estimated predicted probabilities for self-harm or attempted suicide based on sexual identity and MHP-HRB co-occurrence status using logistic regression models with appropriate interaction terms (between sexual identity and MHP-HRB co-occurrence status variables).
Results: MHP prevalence was higher in gay/lesbian (48%) and bisexual (49%) adolescents compared to heterosexual peers (19%). Self-harm (bisexual, 64%; gay/lesbian, 53%; heterosexual, 19%) and attempted suicide (bisexual, 24%; gay/lesbian, 17%; heterosexual, 6%) prevalence were higher in SMA compared to heterosexual peers. Gay/lesbian and bisexual adolescents consistently had higher probability for MHP-HRB co-occurrence compared to heterosexual peers (example, for gay/lesbian individuals: RRR 3.16 [95% CI 2.1-4.68] for MHP-1HRB, RRR 3.54 [95% CI 2.06-6.08] for MHP- ≥ 3HRB, for bisexual adolescents: RRR 2.44 [95% CI 1.85-3.20] for MHP-1HRB, RRR 4.11 [95% CI 2.99-5.66] for MHP- ≥ 3HRB). MHP-HRB co-occurrence and sexual minority identity were independently associated with greater odds for self-harm or attempted suicide. SMA had higher probabilities of reporting self-harm than heterosexual peers with the same level of MHP-HRB co-occurrence. For example, 37.2% of heterosexual adolescents with MHP-1HRB reported self-harm. Corresponding numbers were twice as high in bisexual (75.7%) and gay/lesbian (77.9%) individuals. Similarly, 58.3% of heterosexual adolescents with MHP- ≥ 3HRBs reported self-harm, increasing to 84.6% in bisexual and 83.8% in gay/lesbian peers.
Conclusions: SMA are more likely to experience MHP-HRB co-occurrence, which is associated with substantially higher risks for self-harm and attempted suicide compared to heterosexual peers. Findings highlight the need for better public health policies to address MHP and associated comorbidities to reduce sexual identity-related health inequities in adolescence.
背景:性少数青少年(SMA)的心理健康问题(MHP,如抑郁/焦虑)和健康与风险行为(HRBs)比异性恋同龄人更常见。有限的研究调查了精神健康状况不佳和hrb的共同发生,如果共同发生的情况因性别身份而异,以及青少年自我伤害和企图自杀的相关风险。方法:本研究包括来自英国千禧年队列研究的10233名17岁青少年(51%为女性/11%为性少数群体)。性别认同、MHP、七项hrb(如经常吸烟、吸毒和性危险行为)、自残和企图自杀都是自我报告的。采用抑郁/焦虑情绪症状量表(SDQ)对MHP进行评估。我们使用多项逻辑回归评估了性别认同与MHP和HRBs共存之间的关系。我们基于性别认同和MHP-HRB共现状态使用逻辑回归模型估计自残或企图自杀的预测概率,该模型具有适当的相互作用项(在性别认同和MHP-HRB共现状态变量之间)。结果:男同性恋/女同性恋(48%)和双性恋(49%)青少年的MHP患病率高于异性恋同龄人(19%)。自残(双性恋,64%;男/女同性恋,53%;异性恋,19%)和企图自杀(双性恋,24%;男/女同性恋,17%;异性恋,6%)的SMA患病率高于异性恋同龄人。男同性恋/女同性恋和双性恋青少年与异性恋同龄人相比,MHP- 1hrb共发生的概率一贯较高(例如,男同性恋/女同性恋个体:MHP- 1hrb的RRR为3.16 [95% CI 2.1-4.68], MHP-≥3HRB的RRR为3.54 [95% CI 2.06-6.08],双性恋青少年:MHP- 1hrb的RRR为2.44 [95% CI 1.85-3.20], MHP-≥3HRB的RRR为4.11 [95% CI 2.99-5.66])。MHP-HRB的共存和性少数身份与自残或企图自杀的可能性有较大的独立关系。与MHP-HRB共存水平相同的异性恋同龄人相比,SMA报告自残的概率更高。例如,37.2%患有MHP-1HRB的异性恋青少年报告有自残行为。在双性恋(75.7%)和男同性恋/女同性恋(77.9%)人群中,相应的数字是这个数字的两倍。同样,58.3%的MHP-≥3HRBs的异性恋青少年报告自残,双性恋增加到84.6%,同性恋增加到83.8%。结论:与异性恋同龄人相比,SMA更有可能经历MHP-HRB共存,这与自残和自杀未遂的风险显著增加有关。研究结果强调需要更好的公共卫生政策来解决MHP和相关的合并症,以减少青春期与性身份相关的卫生不平等。
期刊介绍:
BMC Medicine is an open access, transparent peer-reviewed general medical journal. It is the flagship journal of the BMC series and publishes outstanding and influential research in various areas including clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedical and sociomedical professional communities. In addition to research articles, the journal also publishes stimulating debates, reviews, unique forum articles, and concise tutorials. All articles published in BMC Medicine are included in various databases such as Biological Abstracts, BIOSIS, CAS, Citebase, Current contents, DOAJ, Embase, MEDLINE, PubMed, Science Citation Index Expanded, OAIster, SCImago, Scopus, SOCOLAR, and Zetoc.