Precise Modulation of BCB Reactive Sites via Lewis/Brønsted Acid Switching for the Synthesis of Spirocycles and Bridged Frameworks.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-09 DOI:10.1021/acs.orglett.5c02160

Ming-Ming Li,Teng-Fei Xiao,Yi-Xiang Geng,Guo-Qiang Xu,Peng-Fei Xu

引用次数: 0

Abstract

Bicyclo[1.1.0]butanes (BCBs), which possess multiple switchable reactive sites, serve as the most direct modular scaffolds for constructing benzene ring bioisosteres. Herein, we describe the precise modulation of BCB reactive sites through Lewis/Brønsted acid switching to enable the synthesis of challenging spirocycles and bridged frameworks. The divergent reaction outcomes, arising from the precise control of catalysts over the switchable reactive sites of BCBs, are achieved without any substrate modification.

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Lewis/Brønsted酸开关对BCB反应位点的精确调节用于螺旋环和桥接框架的合成。

双环[1.1.0]丁烷（BCBs）具有多个可切换的活性位点，是构建苯环生物同位酯最直接的模块化支架。在本文中，我们描述了通过Lewis/Brønsted酸转换对BCB反应位点的精确调节，以合成具有挑战性的螺旋环和桥接框架。不同的反应结果源于催化剂对bcb可切换反应位点的精确控制，而无需对底物进行任何修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.