Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort.

IF 4.8 2区医学 Q1 GENETICS & HEREDITY

Clinical Epigenetics Pub Date : 2025-07-07 DOI:10.1186/s13148-025-01893-1

Dzevka Dragic, Fanny Artaud, Mojgan Karimi, Thérèse Truong, Laura Baglietto, Jean-François Deleuze, Caroline Diorio, Gianluca Severi

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引用次数: 0

Abstract

Background: Alcohol consumption can have harmful effects on health, depending on the quantity and frequency. Understanding the underlying molecular mechanisms is essential to grasp its health consequences. The study aimed to assess the association between alcohol consumption and blood DNA methylation, an epigenetic mechanism that controls gene expression.

Methods: The epigenome-wide association study (EWAS) included 1,538 women from a case-cohort study within the French E3N cohort. Weighted linear mixed-effects models were used to assess the associations between self-reported alcohol consumption (in g/day in 1993) and DNA methylation at 715,986 CpGs measured with the HumanMethylationEPIC Beadchip. Women were cancer-free at blood collection in 1995-1999.

Results: Of the 715,986 sites analyzed, 19,255 were associated with alcohol consumption (FDR < 0.05). Over-representation analysis highlighted enrichment of genes involved in cancer, the nervous system and aging. Of these 19,255 sites, 1,528 were replicated in an independent case-control study, with 85 also identified in other EWAS. Notably, at least six studies reported sites in SLC7A11, ANP32B, MCM2, HNRNPA1, SNORD30, and TRA2B genes.

Conclusions: Several potential methylation markers for alcohol consumption, documented prior to blood sampling, have been identified. The link between these sites and chronic diseases should be investigated to understand the molecular mechanisms underlying the harmful effects of alcohol consumption on health.

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饮酒和DNA甲基化：法国E3N队列的全表观基因组关联研究

背景：根据饮酒的数量和频率不同，饮酒会对健康产生有害影响。了解潜在的分子机制对于掌握其健康后果至关重要。该研究旨在评估饮酒与血液DNA甲基化之间的关系，甲基化是一种控制基因表达的表观遗传机制。方法：全表观基因组关联研究（EWAS）包括来自法国E3N队列的病例队列研究的1538名妇女。使用加权线性混合效应模型来评估自我报告的酒精摄入量（1993年以g/天为单位）与使用HumanMethylationEPIC珠片测量的715,986个CpGs的DNA甲基化之间的关系。在1995-1999年的血液采集中，妇女无癌症。结果：在分析的715,986个位点中，19,255个位点与饮酒有关(FDR结论：在血液采样之前记录的几个潜在的饮酒甲基化标记已被确定。应该调查这些位点与慢性疾病之间的联系，以了解饮酒对健康有害影响的分子机制。

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来源期刊

Clinical Epigenetics ONCOLOGY-

自引率

5.30%

发文量

150

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.