Oncoviral Infection and the Significance of Reactive Oxygen Species: From Mechanisms to Therapeutic Significance.

IF 5.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ruixue Sang, Xia Zhao, Ketao Sun, Yan Zhang, Bing Luo
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引用次数: 0

Abstract

Significance: Reactive oxygen species (ROS) are a double-edged sword in the context of oncoviruses. The effects of ROS on cells depend on the cellular environment, the stage of the disease, and the specific molecular pathways involved. In general, ROS levels in oncovirus-infected cells are usually increased and produce two distinct outcomes on cancer progression and metastasis through multiple mechanisms. Therefore, identifying the relationship between ROS and tumor viruses at the molecular level is essential for cancer prevention and treatment. Recent Advances: ROS play an important role in oncoviral infection and disease progression. The excessive accumulation of ROS induces ferroptosis, which has an important role in tumor therapy and the immune microenvironment, thus providing a theoretical basis for the development of new anticancer treatment strategies. Critical Issues: This review summarizes the complex relationship between ROS and oncoviral infection, with the aim of providing a deeper understanding of tumor pathogenesis and new therapeutic strategies. Future Directions: The relationship between ROS induced by oncoviral infection and host metabolic pathways, including lipids, lipoproteins, amino acids, and polyamines. Understanding how metabolism is reprogrammed in cancer cells may elucidate the impact of these processes on viral infection and tumor progression and help develop effective treatment strategies. Antioxid. Redox Signal. 00, 000-000.

肿瘤病毒感染与活性氧的意义:从机制到治疗意义。
意义:活性氧(ROS)在肿瘤病毒中是一把双刃剑。活性氧对细胞的影响取决于细胞环境、疾病的阶段和所涉及的特定分子途径。通常,在癌病毒感染的细胞中,ROS水平通常升高,并通过多种机制在癌症进展和转移中产生两种不同的结果。因此,在分子水平上明确ROS与肿瘤病毒的关系,对于癌症的预防和治疗至关重要。最新进展:活性氧在肿瘤病毒感染和疾病进展中起重要作用。ROS的过度积累诱导铁下垂,在肿瘤治疗和免疫微环境中具有重要作用,从而为开发新的抗癌治疗策略提供了理论依据。关键问题:本文综述了活性氧与肿瘤病毒感染之间的复杂关系,旨在为深入了解肿瘤发病机制和新的治疗策略提供帮助。未来发展方向:肿瘤病毒感染诱导的活性氧与宿主代谢途径的关系,包括脂质、脂蛋白、氨基酸和多胺。了解癌细胞中的代谢是如何重编程的,可以阐明这些过程对病毒感染和肿瘤进展的影响,并有助于制定有效的治疗策略。Antioxid。氧化还原信号:00000 - 00000。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antioxidants & redox signaling
Antioxidants & redox signaling 生物-内分泌学与代谢
CiteScore
14.10
自引率
1.50%
发文量
170
审稿时长
3-6 weeks
期刊介绍: Antioxidants & Redox Signaling (ARS) is the leading peer-reviewed journal dedicated to understanding the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease. The Journal explores key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics. Cutting-edge research focuses on structural biology, stem cells, regenerative medicine, epigenetics, imaging, clinical outcomes, and preventive and therapeutic nutrition, among other areas. ARS has expanded to create two unique foci within one journal: ARS Discoveries and ARS Therapeutics. ARS Discoveries (24 issues) publishes the highest-caliber breakthroughs in basic and applied research. ARS Therapeutics (12 issues) is the first publication of its kind that will help enhance the entire field of redox biology by showcasing the potential of redox sciences to change health outcomes. ARS coverage includes: -ROS/RNS as messengers -Gaseous signal transducers -Hypoxia and tissue oxygenation -microRNA -Prokaryotic systems -Lessons from plant biology
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