CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-07-08 DOI:10.1038/s42255-025-01324-8

Julie Mie Jacobsen, Jens Frey Halling, Ida Blom, Jaime Moreno Martinez, Bjørn Hald, Kent Pedersen, Johannes Josef Fels, Søren Snitker, Anna Secher, Sofia Lundh, Carel W. le Roux, Kirsten Raun, Marc L. Reitman, Rune Ehrenreich Kuhre

引用次数: 0

Abstract

CagriSema is a combination of amylin (cagrilintide) and glucagon-like peptide-1 (semaglutide) analogues being developed for weight management. Here, we show that CagriSema blunts metabolic adaptation in rats. Quantifying CagriSema’s action on energy intake and expenditure in rats we observe 12% weight loss with a 39% reduction in food intake. By contrast, pair-feeding causes less-pronounced weight loss, while weight matching requires a 51% decrease in food intake. Therefore, approximately one-third of CagriSema’s weight loss efficacy arises from an effect on energy expenditure, the blunting of metabolic adaptation, which contributes to the successful treatment of obesity.

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CagriSema通过减少能量摄入和保持能量消耗来促进大鼠体重减轻

CagriSema是胰高血糖素（cagrilintide）和胰高血糖素样肽-1 （semaglutide）类似物的组合，正在开发用于体重管理。在这里，我们表明CagriSema会削弱大鼠的代谢适应。量化CagriSema对大鼠能量摄入和消耗的作用，我们观察到体重减轻12%，食物摄入量减少39%。相比之下，配对喂养导致的体重下降不太明显，而体重匹配需要减少51%的食物摄入量。因此，大约三分之一的CagriSema减肥功效来自于对能量消耗的影响，代谢适应的钝化，这有助于成功治疗肥胖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.