Perinatal outcome of pregnant mothers with active rubella infection in a tertiary hospital in Nigeria.

Beatrice O Owolabi, Kikelolmo T Adesina, Omotayo O Adesiyun, Abayomi Fadeyi, Adebunmi O Olarinoye, Sherifat T Suleiman, James O Owolabi, Dele O Amadu
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Abstract

Objective: To determine the seroprevalence of the rubella virus among pregnant women and the perinatal outcome of neonates of mothers with active rubella virus.

Design: A cross-sectional and longitudinal study.

Setting: The study was conducted in the Obstetrics and Gynaecology Department of a teaching hospital in Nigeria.

Participants: Pregnant women at the gestational age of 18-20 weeks.

Intervention: Screening pregnant mothers for immunoglobulin (IgG, IgM) for the rubella virus. Neonates of pregnant mothers with active rubella infection (IgM positive) were screened at birth for rubella IgM to assess for congenital rubella infections and congenital rubella syndrome.

Main outcome measure: Prevalence of rubella immunoglobulin G and active rubella infection IgM, congenital rubella infection, and congenital rubella syndrome.

Results: Of the 327 participants, 68.8% were rubella IgG seropositive, while 7.6% were Rubella IgM seropositive. Fifty-six (56) per cent of neonates of women with active rubella infection were Rubella IgM seropositive at birth, and 14.3% of the neonates of Rubella IgM seropositive pregnant women with active rubella infection had occipitofrontal circumference of less than 10th percentile for gestational age.

Conclusion: Rubella virus is present in our environment with the risk of pregnant mother and neonate of being infected.

Funding: None declared.

尼日利亚一家三级医院风疹活动性感染孕妇的围产期结局。
目的:了解孕妇风疹病毒血清阳性率及风疹病毒活动性母亲的新生儿围产儿结局。设计:横断面和纵向研究。环境:本研究在尼日利亚一所教学医院的妇产科进行。参与者:孕周18-20周的孕妇。干预措施:对孕妇进行风疹病毒免疫球蛋白(IgG, IgM)筛查。活动性风疹感染(IgM阳性)孕妇的新生儿在出生时进行风疹IgM筛查,以评估先天性风疹感染和先天性风疹综合征。主要结局指标:风疹免疫球蛋白G和活动性风疹感染IgM、先天性风疹感染和先天性风疹综合征的患病率。结果:327名参与者中,风疹IgG血清阳性68.8%,风疹IgM血清阳性7.6%。56 %的风疹活动性感染孕妇的新生儿出生时风疹IgM血清阳性,14.3%的风疹活动性感染孕妇的新生儿枕额围小于胎龄的10个百分位。结论:风疹病毒存在于环境中,孕妇和新生儿有感染风疹病毒的危险。资金:未宣布。
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