Role of Oral and Esophageal Microbiota in Esophageal Squamous Cell Carcinoma.

IF 1.9 4区 医学 Q3 ONCOLOGY
Clinical Medicine Insights-Oncology Pub Date : 2025-07-03 eCollection Date: 2025-01-01 DOI:10.1177/11795549251350185
Kong Jinyu, Wang Jian, Liu Yiwen, Li Ruonan, Gao Shegan
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Abstract

In China, esophageal cancer (EC) is one of the most prevalent malignant tumors of the digestive system. EC has a high incidence and mortality rate, of which esophageal squamous cell carcinoma (ESCC) accounts for more than 90%. Due to a lack of effective prevention and treatment methods, the 5 year survival rate is less than 30%. In recent years, microecology has become a hot spot in cancer research, and dysbiosis may play an important role in the etiology of EC. Presently, research on the relationship between the microbiome and ESCC remains in its early stages. This narrative review examines the relationship between the oral and esophageal microbiota and ESCC. A better understanding of this relationship may facilitate early detection and the optimization of treatment strategies.

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口腔和食管微生物群在食管鳞状细胞癌中的作用。
在中国,食管癌是最常见的消化系统恶性肿瘤之一。食管鳞状细胞癌发病率高,死亡率高,其中食管鳞状细胞癌(ESCC)占90%以上。由于缺乏有效的预防和治疗方法,5年生存率不足30%。近年来,微生态学已成为癌症研究的热点,生态失调可能在EC的病因学中发挥重要作用。目前,关于微生物组与ESCC之间关系的研究仍处于早期阶段。本文综述了口腔和食管微生物群与ESCC之间的关系。更好地了解这种关系可能有助于早期发现和优化治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.40
自引率
4.50%
发文量
57
审稿时长
8 weeks
期刊介绍: Clinical Medicine Insights: Oncology is an international, peer-reviewed, open access journal that focuses on all aspects of cancer research and treatment, in addition to related genetic, pathophysiological and epidemiological topics. Of particular but not exclusive importance are molecular biology, clinical interventions, controlled trials, therapeutics, pharmacology and drug delivery, and techniques of cancer surgery. The journal welcomes unsolicited article proposals.
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