Cervical Cancer in Pregnancy: A 10-Year Retrospective Analysis of Clinical Management and Future Perspectives.

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-07-06 DOI:10.1177/15330338251356924
Yuliang Sun, Weishi Cheng, Jing Shen, Hongnan Zhen, Hui Guan, Lei He, Ke Hu, Fuquan Zhang, Zhikai Liu
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Abstract

IntroductionThis study aims to evaluate diagnosis, treatment and clinical outcomes for patients with cervical cancer in pregnancy (CCIP) and their fetuses over a 10-year period, providing clinical evidence for the management of CCIP.MethodsClinical data of 28 patients diagnosed with CCIP at our center between January 1st, 2013 and June 30th, 2023 were retrospectively analyzed, focusing on gestational age at diagnosis, treatment, and maternal-fetal outcomes.ResultsA total of 28 patients with CCIP were identified, accounting for 0.42% (28/6678) of patients with cervical cancer during the study period. The majority of patients (86%, 24/28) had squamous cell carcinoma diagnosed by colposcopic biopsy, and 21 patients presented with recurrent vaginal bleeding. Cervical cancer was diagnosed during pregnancy in 19 cases and in the postpartum period in 9 cases. The mean tumor diameter was 5.4 (2-12) cm. Among 19 patients diagnosed during pregnancy, 13 patients chose pregnancy preservation, resulting in an average delay of treatment by 16.4 (0-33) weeks without observed disease progression. Fetuses were delivered via cesarean section at an average gestational age of 36.3 weeks; eight of these patients received neoadjuvant chemotherapy. At a median follow-up duration of 40.1 (12-103) months, 25 patients survived. Disease-free survival was observed in 20 patients, whereas two patients experienced local progression, and six developed distant metastases.ConclusionClinical outcomes for patients with CCIP appear comparable to those observed in non-pregnant patients in the general population. Pregnant patients presenting with abnormal vaginal bleeding should undergo prompt cervical cancer screening to enable early diagnosis and tailored management strategies. For patients with a strong desire to maintain their pregnancy, careful consideration should be given to postponing delivery until fetal maturity, thereby minimizing maternal and fetal complications and improving maternal and fetal outcomes.

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妊娠期宫颈癌:10年临床管理回顾性分析及未来展望。
本研究旨在评估妊娠期宫颈癌(CCIP)患者及其胎儿10年的诊断、治疗和临床结果,为CCIP的治疗提供临床依据。方法回顾性分析2013年1月1日至2023年6月30日28例CCIP患者的临床资料,重点分析诊断、治疗时的胎龄及母胎结局。结果共检出CCIP患者28例,占研究期间宫颈癌患者的0.42%(28/6678)。大多数患者(86%,24/28)经阴道镜活检诊断为鳞状细胞癌,21例患者出现复发性阴道出血。宫颈癌在怀孕期间确诊19例,在产后确诊9例。平均肿瘤直径为5.4 (2-12)cm。在19例妊娠期诊断的患者中,13例患者选择保留妊娠,导致平均延迟治疗16.4(0-33)周,未观察到疾病进展。胎儿在平均胎龄36.3周时通过剖宫产分娩;其中8例患者接受了新辅助化疗。中位随访时间为40.1(12-103)个月,25例患者存活。20例患者无病生存,2例出现局部进展,6例发生远处转移。结论CCIP患者的临床结果与普通人群中未怀孕患者的临床结果相似。出现阴道异常出血的孕妇应及时进行宫颈癌筛查,以便及早诊断和制定有针对性的管理策略。对于有强烈妊娠意愿的患者,应慎重考虑推迟分娩至胎儿成熟,从而最大限度地减少母胎并发症,改善母胎结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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