{"title":"From the microscopic gladiator pit: Antibiotics vs resistance.","authors":"Nishad Matange","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The discovery of antibiotics in the early to mid-1900s has shaped modern medicine. From treating bacterial infections to preventing them during surgeries or cancer therapy, antibiotics are an essential pillar of human health. Beyond therapeutics for humans, our ability to mass produce dairy or meat products relies on the protective shield that antibiotics provide against communicable bacterial diseases. Yet, even as modern societies started to reap the benefits of antibiotics, the threat of antibiotic resistance (more generally, antimicrobial resistance, or AMR) had emerged. As early as 1940, resistance to penicillin in <i>Escherichia coli</i> was reported (Abraham and Chain 1940). Very soon after its use to treat bacterial infections in clinics, resistance was also reported from <i>Staphylococcus</i> (Rammelkamp and Maxon 1942). The same story repeated with every new antibiotic over the next 80 years (Hutchings <i>et al.</i> 2019). Today AMR is widespread and has been dubbed a silent pandemic.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biosciences","FirstCategoryId":"99","ListUrlMain":"","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The discovery of antibiotics in the early to mid-1900s has shaped modern medicine. From treating bacterial infections to preventing them during surgeries or cancer therapy, antibiotics are an essential pillar of human health. Beyond therapeutics for humans, our ability to mass produce dairy or meat products relies on the protective shield that antibiotics provide against communicable bacterial diseases. Yet, even as modern societies started to reap the benefits of antibiotics, the threat of antibiotic resistance (more generally, antimicrobial resistance, or AMR) had emerged. As early as 1940, resistance to penicillin in Escherichia coli was reported (Abraham and Chain 1940). Very soon after its use to treat bacterial infections in clinics, resistance was also reported from Staphylococcus (Rammelkamp and Maxon 1942). The same story repeated with every new antibiotic over the next 80 years (Hutchings et al. 2019). Today AMR is widespread and has been dubbed a silent pandemic.
20世纪初到中期抗生素的发现塑造了现代医学。从治疗细菌感染到在手术或癌症治疗期间预防细菌感染，抗生素是人类健康的重要支柱。除了对人类的治疗，我们大规模生产乳制品或肉制品的能力依赖于抗生素对传染性细菌疾病的保护。然而，即使现代社会开始从抗生素中获益，抗生素耐药性（更一般地说，抗菌素耐药性，简称AMR）的威胁也已经出现。早在1940年就报道了大肠杆菌对青霉素的耐药性（Abraham and Chain 1940）。在将其用于治疗临床细菌感染后不久，葡萄球菌也报告了耐药性（Rammelkamp和Maxon 1942）。在接下来的80年里，每一种新的抗生素都在重复同样的故事（Hutchings et al. 2019）。今天，抗菌素耐药性很普遍，被称为无声的流行病。
期刊介绍：
The Journal of Biosciences is a quarterly journal published by the Indian Academy of Sciences, Bangalore. It covers all areas of Biology and is the premier journal in the country within its scope. It is indexed in Current Contents and other standard Biological and Medical databases. The Journal of Biosciences began in 1934 as the Proceedings of the Indian Academy of Sciences (Section B). This continued until 1978 when it was split into three parts : Proceedings-Animal Sciences, Proceedings-Plant Sciences and Proceedings-Experimental Biology. Proceedings-Experimental Biology was renamed Journal of Biosciences in 1979; and in 1991, Proceedings-Animal Sciences and Proceedings-Plant Sciences merged with it.
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