Rh-Catalyzed Atroposelective Single-Carbon Insertion.

IF 14.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Bowen Li, Valero G Alfonso, Alessio Puggioli, Albert Solé-Daura, Feliu Maseras, Marcos G Suero
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引用次数: 0

Abstract

Single-carbon insertion processes have gained considerable momentum over the past few years. Although innovative methods have emerged for converting indole or indene into quinoline or naphthalene cores, the enantioselective version of such ring-expansions to create (hetero)biaryl atropisomers has not been developed. Herein, we report the first enantioselective single-carbon insertion that converts 3-aryl indoles to atropochiral quinolines. Key in the process was the generation of a chiral Rh-carbynoid that mediated in the creation of the stereogenic C(sp2)-C(sp2) axis.

铑催化的反选择性单碳插入。
单碳插入工艺在过去几年中获得了相当大的发展势头。虽然已经出现了将吲哚或吲哚转化为喹啉或萘核心的创新方法,但尚未开发出这种环扩展的对映选择性版本,以产生(杂)联芳基atropisomer。在这里,我们报道了第一个对映选择性单碳插入,将3-芳基吲哚转化为atropo手性喹啉。该过程的关键是手性类rh碳的产生,介导了立体C(sp2)-C(sp2)轴的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
24.40
自引率
6.00%
发文量
2398
审稿时长
1.6 months
期刊介绍: The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.
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