Observation of the efficacy and safety of concurrent intensity-modulated radiation with 5-fluorouracil and oxaliplatin for locally advanced nasopharyngeal carcinoma

IF 1.4 4区医学 Q4 ONCOLOGY

Cancer Radiotherapie Pub Date : 2025-07-01 DOI:10.1016/j.canrad.2025.104668

Li Yanbing, Cai Lingyu, Zuo Hongbo, Li Zijun

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Abstract

Purpose

The purpose of this study was to investigate the clinical efficacy and safety of concurrent intensity-modulated radiotherapy in combination with 5-fluorouracil and oxaliplatin for patients diagnosed with locally advanced nasopharyngeal carcinoma.

Material and methods

A total 66 patients with a newly diagnosed and previously treated locally advanced nasopharyngeal carcinoma were enrolled in this study. The patients were divided into two groups: the control group receiving intensity-modulated radiotherapy with 5-fluorouracil and cisplatin (n = 33) and the observation group receiving intensity-modulated radiotherapy with 5-fluorouracil and oxaliplatin (n = 33). Short-term efficacy, 6-month survival rate, recurrence rate, and distant metastasis rate of tumours were compared between the two groups. Furthermore, the incidence of treatment-related adverse reactions including nausea and vomiting, thrombocytopenia, hepatorenal syndrome, peripheral neuritis, and oral mucosa reaction was recorded.

Results

The overall efficacy rate of short-term treatment in the observation group was 96.97 %, compared to 93.94 % in the control group, indicating no statistically significant difference (p > 0.05). There were no significant differences observed between the two groups in terms of 6-month survival rate, recurrence rate, and distant metastasis rate (p > 0.05). The incidence of adverse reactions during treatment was 21.21 % in the observation group, which was significantly lower than that of 45.45 % in the control group (p < 0.05).

Conclusion

Concurrent intensity-modulated radiation therapy with 5-fluorouracil and oxaliplatin may achieve similar short-term outcomes as the standard regimen of 5-fluorouracil and cisplatin in the treatment of locally advanced nasopharyngeal carcinoma, with the added benefit of reduced toxicity.

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调强放疗联合5-氟尿嘧啶和奥沙利铂治疗局部晚期鼻咽癌的疗效和安全性观察

目的探讨5-氟尿嘧啶联合奥沙利铂同步调强放疗治疗局部晚期鼻咽癌的临床疗效和安全性。材料和方法本研究共纳入66例新诊断和既往治疗过的局部晚期鼻咽癌患者。将患者分为对照组（33例）和观察组（33例），对照组联合5-氟尿嘧啶顺铂调强放疗，观察组联合5-氟尿嘧啶和奥沙利铂调强放疗。比较两组患者的短期疗效、6个月生存率、复发率及肿瘤远处转移率。此外，还记录了治疗相关不良反应的发生率，包括恶心呕吐、血小板减少、肝肾综合征、周围神经炎和口腔黏膜反应。结果观察组短期治疗总有效率为96.97%，对照组为93.94%，差异无统计学意义(p >；0.05)。两组患者在6个月生存率、复发率和远处转移率方面无显著差异(p >；0.05)。观察组治疗过程中不良反应发生率为21.21%，显著低于对照组的45.45% (p <；0.05)。结论5-氟尿嘧啶联合奥沙利铂同步调强放疗治疗局部晚期鼻咽癌的短期疗效与5-氟尿嘧啶联合顺铂标准方案相似，且具有降低毒性的优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Radiotherapie 医学-核医学

CiteScore

2.20

自引率

23.10%

发文量

129

审稿时长

63 days

期刊介绍： Cancer/radiothérapie se veut d''abord et avant tout un organe francophone de publication des travaux de recherche en radiothérapie. La revue a pour objectif de diffuser les informations majeures sur les travaux de recherche en cancérologie et tout ce qui touche de près ou de loin au traitement du cancer par les radiations : technologie, radiophysique, radiobiologie et radiothérapie clinique.