Microgravity modulates keratinocyte, fibroblast, and endothelial cell communication during wound healing

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-07-06 DOI:10.1016/j.lfs.2025.123842

Mengya Zhao , Xiaofeng Ma , Zhuo Zuo , Yaxing Wang , Yanwei Fang , Yulong Sun

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引用次数: 0

Abstract

In microgravity, skin tissue is particularly susceptible to damage from collisions, increasing the risk of injury for astronauts. This environment often delays wound healing, raising the potential for infections and adversely affecting astronaut health. The interplay between wound healing stages and cytokines in simulated microgravity remains poorly understood despite its importance. Microgravity exposure impacts key cell types in skin healing, including keratinocytes, fibroblasts, and endothelial cells. Noteworthy changes include enhanced keratinocyte migration, reduced fibroblast proliferation, and alterations in endothelial cell morphology and gene expression. These changes can hinder extracellular matrix remodeling and disrupt cell-to-cell adhesion during healing. Furthermore, advanced techniques like single-cell transcriptomics provide valuable insights into the mechanisms of skin wound healing in microgravity. This review highlights new perspectives on the dynamics of skin wound healing under these unique conditions.

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在伤口愈合过程中，微重力调节角化细胞、成纤维细胞和内皮细胞的通讯

在微重力环境下，皮肤组织特别容易受到碰撞的伤害，这增加了宇航员受伤的风险。这种环境往往会延迟伤口愈合，增加感染的可能性，并对宇航员的健康产生不利影响。在模拟微重力环境下，伤口愈合阶段和细胞因子之间的相互作用尽管很重要，但仍然知之甚少。微重力暴露影响皮肤愈合的关键细胞类型，包括角化细胞、成纤维细胞和内皮细胞。值得注意的变化包括角化细胞迁移增强，成纤维细胞增殖减少，内皮细胞形态和基因表达的改变。这些变化会阻碍细胞外基质重塑，并在愈合过程中破坏细胞间的粘附。此外，单细胞转录组学等先进技术为微重力下皮肤伤口愈合机制提供了有价值的见解。这篇综述强调了在这些独特条件下皮肤伤口愈合动力学的新观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.