Two photon fluorescent detection mechanism of the nitric oxide within lysosomes: Theoretical investigation

IF 3.1 3区化学 Q3 CHEMISTRY, PHYSICAL

Chemical Physics Letters Pub Date : 2025-07-04 DOI:10.1016/j.cplett.2025.142275

Bin Han , Yongjin Peng , Yuling Liu

引用次数: 0

Abstract

Detecting the NO concentration in lysosomes is a highly challenging task. This study conducted a detailed theoretical investigation into the NO detection mechanism of one highly efficient two photon fluorescent probe Lyso-NINO. Through quantum chemical calculation methods, the geometric and electronic structures of the probe were theoretically analyzed to elucidate the changes in the electronic structure of the probe molecule before and after reacting with NO. All the theoretical results would provide the insights for deep understanding the design and development of the efficient fluorescent probe to detect the NO concentration in biological system.

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溶酶体内一氧化氮的双光子荧光检测机制：理论研究

溶酶体中NO浓度的检测是一项极具挑战性的任务。本研究对高效双光子荧光探针Lyso-NINO检测NO的机理进行了详细的理论探讨。通过量子化学计算方法，对探针的几何结构和电子结构进行了理论分析，阐明了探针分子与NO反应前后电子结构的变化。这些理论结果将为深入理解高效荧光探针检测生物系统中NO浓度的设计和开发提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Physics Letters 化学-物理：原子、分子和化学物理

CiteScore

5.70

自引率

3.60%

发文量

798

审稿时长

33 days

期刊介绍： Chemical Physics Letters has an open access mirror journal, Chemical Physics Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Chemical Physics Letters publishes brief reports on molecules, interfaces, condensed phases, nanomaterials and nanostructures, polymers, biomolecular systems, and energy conversion and storage. Criteria for publication are quality, urgency and impact. Further, experimental results reported in the journal have direct relevance for theory, and theoretical developments or non-routine computations relate directly to experiment. Manuscripts must satisfy these criteria and should not be minor extensions of previous work.