Ti-Catalyzed Functional Group Tolerant and Regioselective Cross Couplings of (Hetero)aryl Grignard Reagents with Halopyridines.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-07 DOI:10.1021/acs.orglett.5c02166

Jin-Long Zhao,Jun-Ting Li,Jing-Yan Kong,Xin-Fang Duan

引用次数: 0

Abstract

We report an unprecedented Ti-catalyzed functional group tolerant and regioselective coupling reaction where (hetro)aryl Grignard reagents are coupled with halopyridines and haloquinolines through an SRN pathway. A simple titanate catalyst not only triggered radical anion generation and the corresponding SRN couplings but also enabled high functional group tolerance and regioselectivity. Highly electron-deficient functionalized Grignard reagents were quite involved in such reactions, and a variety of valuable arylpyridines, bipyridines, and terpyridines were assembled facilely.

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（杂）芳基格氏试剂与卤吡啶的钛催化功能基耐受性和区域选择性交叉偶联。

我们报道了一个前所未有的钛催化的官能团耐受性和区域选择性偶联反应，其中（杂）芳基格氏试剂通过SRN途径与卤代吡啶和卤代喹啉偶联。一个简单的钛酸盐催化剂不仅可以引发自由基阴离子的生成和相应的SRN偶联，而且具有很高的官能团耐受性和区域选择性。高度缺电子的官能化格氏试剂参与了这些反应，各种有价的芳基吡啶、联吡啶和三吡啶被很容易地组装起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.