Adverse Drug Reaction-Related Hospital Admissions in Older Adults with Diabetes: Incidence and Implicated Drug Classes.

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-07-03 DOI:10.1016/j.eprac.2025.06.026

Azizah Vonna, Mohammed S Salahudeen, Gregory M Peterson

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Abstract

Objectives: Adverse drug reaction (ADR)-related hospital admissions are common among older adults. However, those with diabetes have received little research attention with respect to ADRs in recent years, despite the rising prevalence of diabetes and its associated multimorbidity. This study aimed to examine temporal trends in ADR-related hospital admissions among older adults with diabetes, compared to those without diabetes.

Methods: The National Minimum Dataset from the three major public hospitals in Tasmania, Australia, was used to identify all individuals aged ≥65 years hospitalised between 2017 and 2023. International Classification of Diseases Tenth Revision, Australian Modification (ICD-10-AM) codes were used to identify patients with diabetes and ADR-related hospital admissions. Rates of ADR-related hospital admissions were expressed as estimated incidence rate (IR) in the population corresponding to the hospitals' catchment area.

Results: Between 2018 and 2022, the estimated sex-adjusted IR of ADR-related hospital admissions remained stable in the diabetes group (39.9 to 40.3 per 1,000 person-years; p=0.85) and decreased in the non-diabetes group (17.8 to 14.8 per 1,000 person-years; p <0.001). The IR ratio of an ADR-related admission in those with diabetes, compared to those without diabetes, increased over the same period (p<0.05), from 2.24 (95% CI: 2.03-2.47) to 2.72 (95% CI: 2.48-2.98). Corticosteroids, anticoagulants and antihypertensives were major contributors to ADR-related admissions in older adults with diabetes.

Conclusions: ADR-related hospital admissions were consistently more common in older adults with diabetes, compared to those without diabetes. These findings underscore the need for targeted medication safety strategies in this high-risk population.

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老年糖尿病患者药物不良反应相关住院：发生率和相关药物类别

目的：药物不良反应（ADR）相关住院在老年人中很常见。然而，近年来，尽管糖尿病及其相关的多病患病率不断上升，但糖尿病患者在不良反应方面的研究却很少受到关注。本研究旨在研究老年糖尿病患者与非糖尿病患者之间adr相关住院的时间趋势。方法：使用来自澳大利亚塔斯马尼亚州三家主要公立医院的国家最低数据集来确定2017年至2023年间住院的所有年龄≥65岁的个体。国际疾病分类第十版，澳大利亚修订（ICD-10-AM）代码用于识别糖尿病患者和与药物不良反应相关的住院患者。与药物不良反应相关的住院率表示为医院覆盖区域对应人群的估计发病率（IR）。结果：在2018年至2022年期间，糖尿病组估计的经性别调整的adr相关住院率保持稳定(每1000人年39.9至40.3；P =0.85)，非糖尿病组下降(17.8 - 14.8 / 1000人年；结论：与没有糖尿病的老年人相比，与不良反应相关的住院率在老年糖尿病患者中更为常见。这些发现强调了在这一高危人群中需要有针对性的药物安全策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.