CTHRC1 overexpression in gastric cancer patients contributes to a poor prognosis and is related to immune cell infiltration.

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cellular and molecular biology Pub Date : 2025-07-06 DOI:10.14715/cmb/2025.71.6.6

Tao Guo, Qixin Xie, Hon Deng, Changjun Yu, Changyi Fang

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引用次数: 0

Abstract

Gastric cancer is a common solid tumor of the digestive system, This research aimed to investigate the relationships among CTHRC1 expression, prognostic values and tumor-infiltrating immune cells (TIICs) in GC patients.The expression of CTHRC1 in gastric cancer patients was analyzed using the GEPIA database and the TCGA database. The relationship between CTHRC1 expression and survival of gastric cancer patients was then explored using the Kaplan-Meier Plotter database and TCGA database.Subsequently, we explored whether there was an associative effect between the expression of CTHRC1 and TIICs in gastric cancer tissues. Then we constructed a prognostic model using immunomodulatory genes related to CTHRC1 and verified the specificity and accuracy of the model.Compared with normal tissues, the expression of CTHRC1 was significantly upregulated in gastric cancer tissues. And the high expression of CTHRC1 was associated with poor prognosis of gastric cancer patients.It is suggested that CTHRC1 is a reliable prognostic indicator for predicting the prognosis of gastric cancer patients.Then we successively used univariate and multivariate COX methods to obtain three high-risk immunomodulatory genes (TGFB2, CXCR4 and NT5E) and one low-risk immunomodulatory gene (TNFRSF18) associated with CTHRC1. These four immunomodulatory genes were used to construct a prognostic model for gastric cancer.Gastric cancer patients with high CTHRC1 expression have a poor prognosis and are associated with immune cell infiltration. Therefore, CTHRC1 can be considered as a potentially reliable prognostic indicator for gastric cancer patients.

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胃癌患者CTHRC1过表达导致预后不良，并与免疫细胞浸润有关。

胃癌是一种常见的消化系统实体肿瘤，本研究旨在探讨胃癌患者CTHRC1表达、预后价值与肿瘤浸润免疫细胞（tumor-浸润immune cells， TIICs）的关系。采用GEPIA数据库和TCGA数据库分析胃癌患者CTHRC1的表达情况。然后利用Kaplan-Meier Plotter数据库和TCGA数据库探讨CTHRC1表达与胃癌患者生存的关系。随后，我们探讨了胃癌组织中CTHRC1与TIICs的表达是否存在关联作用。然后我们利用CTHRC1相关的免疫调节基因构建预后模型，并验证模型的特异性和准确性。与正常组织相比，胃癌组织中CTHRC1的表达明显上调。CTHRC1的高表达与胃癌患者预后不良相关。提示CTHRC1是预测胃癌患者预后的可靠预后指标。然后我们先后采用单变量和多变量COX方法获得了与CTHRC1相关的3个高危免疫调节基因（TGFB2、CXCR4和NT5E）和1个低危免疫调节基因（TNFRSF18）。利用这四种免疫调节基因构建胃癌预后模型。胃癌患者CTHRC1高表达预后较差，且与免疫细胞浸润有关。因此，CTHRC1可被认为是胃癌患者潜在可靠的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and molecular biology 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

331

期刊介绍： Cellular and Molecular Biology publishes original articles, reviews, short communications, methods, meta-analysis notes, letters to editor and comments in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology, biophysics, biochemistry, enzymology, physiology and biotechnology in a dynamic cell and tissue biology environment, applied to human, animals, plants tissues as well to microbial and viral cells. The journal Cellular and Molecular Biology is therefore open to intense interdisciplinary exchanges in medical, dental, veterinary, pharmacological, botanical and biological researches for the demonstration of these multiple links.