Metabolic reprogramming in melanoma therapy.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-07-05 DOI:10.1038/s41420-025-02617-3

Dongliang Shen, Lu Zhang, Shun Li, Liling Tang

引用次数: 0

Abstract

Melanoma, a deadly and aggressive cancer, exhibits significant metabolic reprogramming that supports energy production, biosynthesis, and tumor progression. This metabolic adaptation drives melanoma growth, proliferation, metastasis, and therapy resistance, highlighting its potential as a promising target for therapeutic intervention. This review focuses on the latest studies elucidating metabolic pathways involved in melanoma progression, therapeutic response, and resistance. Additionally, the potential of targeting metabolic pathways-either alone or in combination with established therapeutic inhibitors-to block disease progression in melanoma is also discussed. Such insights might improve our understanding of metabolic pathways in melanoma development and foster advancements in melanoma therapy.

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黑色素瘤治疗中的代谢重编程。

黑色素瘤是一种致命的侵袭性癌症，它表现出显著的代谢重编程，支持能量产生、生物合成和肿瘤进展。这种代谢适应驱动黑色素瘤的生长、增殖、转移和治疗抵抗，突出了其作为治疗干预的有希望的靶点的潜力。本文综述了黑色素瘤进展、治疗反应和耐药过程中代谢途径的最新研究。此外，针对代谢途径的潜力-单独或与已建立的治疗抑制剂联合-阻止黑色素瘤的疾病进展也进行了讨论。这些见解可能会提高我们对黑色素瘤发展的代谢途径的理解，并促进黑色素瘤治疗的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.