Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes.

IF 3.7 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

BMC Genomics Pub Date : 2025-07-05 DOI:10.1186/s12864-025-11846-w

Yu Xiao, Yun Xia, Xiaomao Zeng

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引用次数: 0

Abstract

Background: The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of gene expression on sex chromosomes differ drastically from those on autosomes. It is little known if the sexualization of gene expression would have started on homomorphic sex chromosomes.

Results: To investigate the evolutionary patterns of sex-biased expression, we examined four species of spiny frogs, using high-throughput RNA sequencing for gonads and sex-specific tissues. We find little support for both the enrichment of sex-linked genes and the excess of sex-linked gene expression. Additionally, there is no evidence supporting for sex-biased gene expression near the candidate sex-determining locus. We find no significant accumulation of sex-biased genes on sex chromosomes. Further, the homomorphic sex chromosomes do not show evidence of a faster rate of evolution.

Conclusions: The sexualization of sex chromosomes in species with homomorphic sex chromosomes may not be as indispensable as hypothesized.

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具有同态性染色体的刺蛙性别连锁转录本的性别偏倚表达。

背景：染色体上性拮抗突变的积累被认为是驱动性染色体进化的有利因素。然而，经验证据仅限于具有异型性染色体的物种，其中性染色体上的基因表达模式与常染色体上的基因表达模式截然不同。基因表达的性别化是否开始于同态性染色体，这一点尚不清楚。结果：为了研究性别偏向表达的进化模式，我们研究了四种刺蛙，使用高通量RNA测序性腺和性别特异性组织。我们发现很少支持性别连锁基因的富集和性别连锁基因表达的过剩。此外，没有证据支持候选性别决定位点附近的性别偏倚基因表达。我们发现性染色体上没有显著的性别偏向基因积累。此外，同态性染色体并没有显示出进化速度更快的证据。结论：在同态性染色体的物种中，性染色体的性化可能并不像假设的那样不可或缺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Genomics 生物-生物工程与应用微生物

CiteScore

7.40

自引率

4.50%

发文量

769

审稿时长

6.4 months

期刊介绍： BMC Genomics is an open access, peer-reviewed journal that considers articles on all aspects of genome-scale analysis, functional genomics, and proteomics. BMC Genomics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.