DIFFERENT GLYCEMIC VARIABILITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME WITH AND WITHOUT INSULIN RESISTANCE: A PILOT STUDY.

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-07-02 DOI:10.1016/j.eprac.2025.06.020

Alessandro Rizzi, Teresa Polimeno, Maria Laura Leo, Ambra Moriconi, Martina Policriti, Linda Tartaglione, Annamaria Merola, Anna Tropea, Rosanna Apa, Dario Pitocco

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Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder that affects 10-13% of women in reproductive age and it is often associated with insulin resistance (IR). There is lack of evidence about glucose profiles evaluated throughout continuous glucose monitoring (CGM) in women with PCOS, especially according to the presence of IR.

Methods: Women with PCOS ≥18 years old underwent CGM (Freestyle Libre 2, Abbott®) for 14 days. Insulin resistance was defined by homeostatic model assessment for insulin resistance (HOMA-IR) >2 or quantitative insulin sensitivity check index (QUICKI) <0.357. CGM metrics were compared between the two groups. Associations between hormonal assays and CGM metrics were also evaluated.

Results: In 36 women with PCOS, median age 22 [18-26] years, BMI 27.5 (6.6) Kg/m², time in range (TIR, 70-180 mg/dl) and time in tight range (TiTR, 70-140 mg/dl) were comparable between women with and without IR (p>0.05). Independently to the score used to evaluate IR, women with IR presented lower coefficient of variation compared to those without IR (using HOMA-IR, CV non-IR 17.1 [12.0-19.8] vs IR 13.5 [11.2-15.5], p=0.04; using QUICKI non-IR 17.3 [11.2-19.9] vs IR 13.8 [10.9-15.7], p=0.04). Follicle stimulating hormone was also correlated with mean sensor glucose, time spent above 140 mg/dl and glucose management indicator.

Conclusion: Women with PCOS presented overall good glucose control. No differences in TIR and TiTR were detected but women with IR presented lower coefficient of variation.

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有和没有胰岛素抵抗的多囊卵巢综合征妇女的不同血糖变异性：一项初步研究。

简介：多囊卵巢综合征（PCOS）是一种复杂的内分泌和代谢紊乱，影响10-13%的育龄妇女，通常与胰岛素抵抗（IR）相关。缺乏关于PCOS女性连续血糖监测（CGM）中葡萄糖谱评估的证据，特别是根据IR的存在。方法：PCOS≥18岁的女性接受CGM （Freestyle Libre 2, Abbott®）治疗14天。胰岛素抵抗通过胰岛素抵抗稳态模型评估(HOMA-IR) >2或定量胰岛素敏感性检查指数（QUICKI）来定义。结果：36例PCOS女性，中位年龄22[18-26]岁，BMI 27.5 (6.6) Kg/m2，范围时间（TIR, 70-180 mg/dl）和紧密范围时间（TiTR, 70-140 mg/dl）在有和没有IR的女性之间具有可比性（p>0.05）。独立于用于评估IR的评分，有IR的女性比没有IR的女性表现出更低的变异系数(使用HOMA-IR， CV非IR 17.1 [12.0-19.8] vs IR 13.5 [11.2-15.5], p=0.04；使用QUICKI非IR 17.3 [11.2-19.9] vs IR 13.8 [10.9-15.7], p=0.04)。促卵泡激素也与平均传感器葡萄糖、超过140 mg/dl的时间和葡萄糖管理指标相关。结论：PCOS患者血糖控制总体良好。TIR和TiTR没有差异，但IR女性的变异系数较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.