Clinicopathologic characteristics of papillary thyroid carcinoma, tall cell subtype and subtype with tall cell features, an institutional experience

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-07-01 DOI:10.1016/j.humpath.2025.105867

Xueting Jin, Shunsuke Koga, Xiao Zhou, Niaz Z. Khan, Zubair W. Baloch

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Abstract

Papillary thyroid carcinoma (PTC) is categorized into various subtypes, including classic PTC (cPTC) with 0 % tall cell morphology, PTC with tall cell features (PTCtcf) with >0 but <30 % tall cells, and tall cell subtype of PTC (tcsPTC) having ≥30 % tall cells. This case-cohort study investigated the clinicopathologic characteristics of cPTC, PTCtcf, and tcsPTC. Patients with.

tcsPTC subtype were older (mean 50.2 years) than patients with cPTC (42.0 years) and PTCtcf (45.6 years). tcsPTC subtype presented with more advanced tumor stages than cPTC, indicating more aggressive tumor behavior. The frequency of extra-thyroidal extension in tcsPTC (60.1 %) and PTCtcf (39.7 %) was higher than in cPTC (23.6 %). Angioinvasion was more frequent in tcsPTC (15.1 %) than cPTC (7.6 %). Positive margins were more common in PTCtcf (12.4 %) and tcsPTC (23.9 %) than cPTC (4.9 %). tcsPTC and PTCtcf had more tumor foci than cPTC. Recurrent or persistent disease occurred more frequently in PTCtcf (13.2 %) and tcsPTC (6.7 %) compared with cPTC (1.5 %). Kaplan-Meier survival analysis demonstrated that all tcsPTC tumors and those tcsPTC tumors ≤1 cm had worse overall and disease-unrelated survival outcomes compared with cPTC, which was mostly due to second non-thyroid tumors. There were no differences in disease-related survival among the 3 PTC subgroups possibly due to efficacy of radioactive iodine therapy more frequently used for treating PTCtcf and tcsPTC compared with cPTC. In conclusion, the findings highlight the aggressive nature of tcsPTC and PTCtcf and emphasize the value of histologic subtyping in guiding management of thyroid carcinoma.

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甲状腺乳头状癌的临床病理特点，高细胞亚型和具有高细胞特征的亚型，有机构经验。

甲状腺乳头状癌（PTC）分为多种亚型，包括典型的PTC (cPTC)，其高细胞形态为0%，具有高细胞特征的PTC (PTCtcf)，其高细胞特征为> ~ 0

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.