Abrupt decrease in haemoglobin A1C as the first hint of autoimmune haemolytic anaemia.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Daniel Boctor, Marina Heskel, Andrew D Leavitt, Janet N Chu
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引用次数: 0

Abstract

Haemolysis shortens erythrocyte life span, thereby reducing the normal accumulation of glycated haemoglobin. We present a case of a patient with diabetes mellitus who, on routine follow-up to the primary care clinic, was found to have a notable decrease in haemoglobin A1C (HbA1C) without changes in medications, diet or exercise habits. A fructosamine assay indicated that the patient's serum glucose was not well-controlled despite the abnormally low HbA1C. Further laboratory evaluation revealed a new normocytic anaemia, secondary to autoimmune haemolytic anaemia, that explained his unexpected low HbA1C. He was diagnosed with B-cell lymphoma.

糖化血红蛋白突然降低是自身免疫性溶血性贫血的第一个提示。
溶血缩短了红细胞的寿命,从而减少了正常的糖化血红蛋白的积累。我们报告一例糖尿病患者,在初级保健诊所的常规随访中,发现血红蛋白A1C (HbA1C)明显下降,而药物,饮食或运动习惯没有改变。果糖胺测定表明,尽管患者的HbA1C异常低,但患者的血清葡萄糖没有得到很好的控制。进一步的实验室评估显示一种新的正常细胞贫血,继发于自身免疫性溶血性贫血,这解释了他意外的低HbA1C。他被诊断为b细胞淋巴瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMJ Case Reports
BMJ Case Reports Medicine-Medicine (all)
CiteScore
1.40
自引率
0.00%
发文量
1588
期刊介绍: BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
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