Unilateral primary intraosseous carcinoma arising from odontogenic cyst associated with an impacted maxillary third molar in a patient with multifocal jaw lesions: A rare case report

Abstract

Primary intraosseous carcinoma (PIOC) is a rare malignancy arising from odontogenic epithelial remnants within cysts. A 63-year-old male presented with ulceration on the right posterior maxillary palate. Imaging showed multiple intraosseous cystic lesions in both jaws; only the cyst linked to the impacted right maxillary third molar exhibited malignant transformation into invasive squamous cell carcinoma. Diagnosis was confirmed via biopsy, histopathology, and immunohistochemistry. The patient underwent right hemi-maxillectomy with prosthetic rehabilitation.