{"title":"CRISPR-Cas systems: A revolution in genome editing and its diverse applications.","authors":"Joseph Lin, Jun Yang","doi":"10.46439/biomedres.5.050","DOIUrl":null,"url":null,"abstract":"<p><p>The clustered regularly interspaced short palindromic repeats (CRISPR) Cas (CRISPR6 associated protein) system is an advanced adaptive immune system found in prokaryotes. First discovered in1987, CRISPR Cas has revolutionized genetic research in the past two decades. CRISPR-Cas9 the most widespread system enables precise gene editing by creating double strand breaks. Its ease of use and cost-effectiveness has lowered the barrier to entry for genetic research. CRISPR holds immense potential in many fields from agriculture to medicine. In agriculture, CRISPR has accelerated crop improvement by enabling precise gene edits for desirable traits. In medicine, CRISPR holds promise in xenotransplant, cancers and infectious diseases (HIV) treatment. This review traces the historical development of CRISPR-Cas systems, explores their unique applications, and discusses future advancements aimed at enhancing CRISPR's precision and expanding its applications through technologies like prime and base editing.</p>","PeriodicalId":73621,"journal":{"name":"Journal of biomed research","volume":"5 1","pages":"108-114"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225621/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomed research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46439/biomedres.5.050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The clustered regularly interspaced short palindromic repeats (CRISPR) Cas (CRISPR6 associated protein) system is an advanced adaptive immune system found in prokaryotes. First discovered in1987, CRISPR Cas has revolutionized genetic research in the past two decades. CRISPR-Cas9 the most widespread system enables precise gene editing by creating double strand breaks. Its ease of use and cost-effectiveness has lowered the barrier to entry for genetic research. CRISPR holds immense potential in many fields from agriculture to medicine. In agriculture, CRISPR has accelerated crop improvement by enabling precise gene edits for desirable traits. In medicine, CRISPR holds promise in xenotransplant, cancers and infectious diseases (HIV) treatment. This review traces the historical development of CRISPR-Cas systems, explores their unique applications, and discusses future advancements aimed at enhancing CRISPR's precision and expanding its applications through technologies like prime and base editing.
聚集规律间隔短回文重复（CRISPR） Cas （CRISPR6相关蛋白）系统是原核生物中发现的一种高级适应性免疫系统。CRISPR Cas于1987年首次被发现，在过去的20年里给基因研究带来了革命性的变化。CRISPR-Cas9是最广泛使用的系统，通过制造双链断裂来实现精确的基因编辑。它的易用性和成本效益降低了基因研究的进入门槛。CRISPR在从农业到医学的许多领域都具有巨大的潜力。在农业领域，CRISPR通过对理想性状进行精确的基因编辑，加速了作物的改良。在医学上，CRISPR在异种移植、癌症和传染病（HIV）治疗方面具有前景。本文回顾了CRISPR- cas系统的历史发展，探讨了其独特的应用，并讨论了未来的进展，旨在提高CRISPR的精度，并通过诸如起始和碱基编辑等技术扩大其应用范围。
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