The effect of the morpholine derivate amorolfin (Roche 14-4767/002) on the ultrastructure of Candida albicans.

Abstract

Summary:  Amorolfin (Roche 14–4767/002) is a phenylpropyl‐morpholine with a remarkable inhibitory effect on yeasts, dermatophytes, and other filamentous fungi. The pathological changes on the ultrastructure of Candida albicans blastospores produced by amorolfin are demonstrated by transmission electronmicroscopy. A comparison with untreated Candida cells as well as those treated with the imidazole compound oxiconazole was performed.