Hypertriglyceridemia in New-Onset Type 1 Pediatric Diabetes.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pediatric Diabetes Pub Date : 2025-06-26 eCollection Date: 2025-01-01 DOI:10.1155/pedi/8425032

Colleen A Macke, Iman Al-Gadi, Nidhi Bansal, Sarah K Lyons, Aikaterini A Nella

引用次数: 0

Abstract

Hypertriglyceridemia (HTG) in the setting of newly diagnosed diabetes is common in both adult and pediatric populations, as insulin deficiency promotes lipolysis and impairs triglyceride (TG) clearance. Severe HTG (defined as TG levels above 1000 mg/dL) in pediatric patients with new-onset type 1 diabetes mellitus (T1D) is rare; the true incidence and sequela of this phenomenon have not been well characterized. We present a single-center experience on severe HTG in pediatric patients with new-onset T1D between 2013 and 2022 and summarize the cases previously reported in the literature. Our cases display variability in their presentation and in their association with high-risk complications, such as acute pancreatitis. We discuss suggestions of early screening for HTG and pancreatitis in patients with protracted abdominal pain, and close monitoring of those identified to have significant HTG.

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新发1型儿童糖尿病的高甘油三酯血症。

新诊断糖尿病的高甘油三酯血症（HTG）在成人和儿童人群中都很常见，因为胰岛素缺乏促进脂肪分解并损害甘油三酯（TG）的清除。在新发1型糖尿病（T1D）患儿中，严重HTG（定义为TG水平高于1000 mg/dL）是罕见的；这种现象的真实发生率和后遗症尚未得到很好的描述。我们对2013年至2022年期间新发T1D患儿重症HTG进行了单中心研究，并总结了之前文献报道的病例。我们的病例在其表现和与高危并发症（如急性胰腺炎）的关联方面表现出变异性。我们讨论了对持续性腹痛患者早期筛查HTG和胰腺炎的建议，并密切监测那些确定有明显HTG的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Diabetes 医学-内分泌学与代谢

CiteScore

6.60

自引率

14.70%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.