Neoplastic ductal plate malformation pattern rather than von Meyenburg complexes may be an early neoplastic lesion of small duct-type intrahepatic cholangiocarcinoma

IF 2.6 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-07-01 DOI:10.1016/j.humpath.2025.105865

Yasuni Nakanuma , Motoko Sasaki , Yuko Kakuda , Kenichi Harada , Yasunori Sato , Takashi Sugino .

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引用次数: 0

Abstract

Aims

To characterize “neoplastic ductal plate malformation pattern (N-DPMP)” of intrahepatic cholangiocarcinoma (iCCA) and to evaluate whether or not von Meyenburg complexes (VMCs) and VMC-mimics characterized by dysplasia/carcinoma in situ were related to the development of iCCA.

Materials and methods

N-DPMP composed of low-grade neoplastic biliary epithelia and showing ductal plate malformation (DPM) features, VMCs, and VMC-mimics were surveyed in 144 small duct-type (SD)-iCCA cases and 47 large duct-type (LD)-iCCA cases. Genetic alterations were examined by direct sequencing and immunohistochemistry. 536 autopsied livers were used as controls.

Results

N-DPMP was found in 27 cases of SD-iCCA but not in LD-iCCA (p < 0.05). While a tumor totally composed of N-DPMP was found in 4 cases, a tumor composed of N-DPMP and anastomosing CCA and/or conventional CCA was found in the remaining 23 cases, with the latter being larger than the former (p < 0.05). Genetic alterations in N-DPMP parts were also found in anastomosing parts in two cases of N-DPMP with anastomosing CCA, supporting that anastomosing CCA may develop in N-DPMP. VMCs were found frequently in 49 cases of SD-iCCA than in 16 cases of autopsy livers (p < 0.01). VMC-mimics, which were found in 5 of 144 SD-iCCA cases, frequently showed mixture of atypical and benign epithelia with an abrupt transition, suggesting that VMC-mimics may reflect cancerization of VMCs by iCCA.

Conclusions

N-DPMP may be an early neoplastic lesion in approximately one-fifth of SD-iCCA. VMCs may be frequently associated with SD-iCCA, but there is no evidence that VMCs are a precursor of SD-iCCA.

Abstract Image

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小管型肝内胆管癌的早期肿瘤病变可能是肿瘤性导管板畸形型，而不是von Meyenburg复合体。

目的：对肝内胆管癌（iCCA）的“肿瘤性导管板畸形模式（N-DPMP）”进行表征，并评价以不典型增生/原位癌为特征的von Meyenburg复合物（vmc）和VMC-mimics是否与iCCA的发生有关。材料与方法：对144例小管型(SD)-iCCA和47例大管型(LD)-iCCA的N-DPMP、vmc和VMC-mimics进行了调查。通过直接测序和免疫组织化学检测基因改变。536例尸检肝脏作为对照。结果：在27例SD-iCCA中发现N-DPMP，而在LD-iCCA中未发现N-DPMP(结论：N-DPMP可能是约五分之一SD-iCCA的早期肿瘤病变。vmc可能经常与SD-iCCA联系在一起，但没有证据表明vmc是SD-iCCA的前兆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.