Cardiogenic shock requiring VA-ECMO therapy in scorpionism-induced myocarditis

IF 3.7 2区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Alba I. Violino, María Alicia Lozano, Rocio Garcia Moralez, Juan P. Ricarte-Bratti, Julieta Lozita, Elizabeth Y. Ravinovich
{"title":"Cardiogenic shock requiring VA-ECMO therapy in scorpionism-induced myocarditis","authors":"Alba I. Violino,&nbsp;María Alicia Lozano,&nbsp;Rocio Garcia Moralez,&nbsp;Juan P. Ricarte-Bratti,&nbsp;Julieta Lozita,&nbsp;Elizabeth Y. Ravinovich","doi":"10.1002/ehf2.15368","DOIUrl":null,"url":null,"abstract":"<p>It is estimated that approximately 1.2 million scorpion stings occur globally each year. However, the true incidence is likely underestimated due to underreporting, particularly in endemic regions with limited access to healthcare systems. While the vast majority of stings result in only local symptoms, approximately 5% of patients develop systemic manifestations, and up to 1% progress to life-threatening complications such as acute heart failure, arrhythmias and cardiogenic shock.<span><sup>1</sup></span></p><p>Scorpion envenomation represents a significant public health issue in tropical and subtropical regions, including parts of Latin America. This case occurred in Córdoba, Argentina, a temperate region in the central part of the country characterized by hot summers and mild winters. The city of Córdoba, where the patient was treated, is a large urban centre surrounded by hilly terrain and natural scorpion habitats. <i>Tityus trivittatus</i>, the most medically relevant scorpion species in Argentina, is endemic to the area, with increasing reports of envenomation during the warm season.<span><sup>2</sup></span></p><p>Cardiovascular complications are among the most severe and life-threatening effects of systemic scorpion envenomation. In a systematic review of over 700 reported cases of scorpion-related myocarditis, pulmonary oedema occurred in approximately 60.7% of cases, and hypotension or cardiogenic shock in 45.8%. Sinus tachycardia was the most common ECG abnormality (82%), followed by ST-T changes (64.6%), with less frequent findings such as ventricular arrhythmias and atrioventricular blocks. Echocardiographic evaluations often reveal global or regional hypokinesia, ventricular dilation and reduced left ventricular ejection fraction (EF)—frequently below 40%. Right ventricular dysfunction and functional mitral or tricuspid regurgitation may also be observed. Despite the severity of these manifestations, many patients—particularly children—exhibit rapid and complete recovery with timely supportive care.<span><sup>3, 4</sup></span></p><p>Although the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been documented in paediatric patients with severe envenomation, no previous cases have been reported in adults.<span><sup>5</sup></span> We present what is, to our knowledge, the first documented case of successful VA-ECMO support in an adult patient with cardiogenic shock secondary to <i>Tityus trivittatus</i> envenomation, underscoring the importance of early recognition and aggressive intervention in such critical scenarios.</p><p>A 21 year-old female with no significant past medical history presented to the emergency department with acute onset of sharp pain in the right foot, radiating proximally along the lower limb, accompanied by sudden-onset vomiting. On admission, she was haemodynamically stable with normal vital signs. According to the patient and her family, the symptoms began approximately 4 h following a suspected scorpion sting to the right foot.</p><p>During the initial evaluation, the patient exhibited progressive clinical deterioration characterized by respiratory distress, tachypnoea (respiratory rate: 32 breaths/min), hypotension (blood pressure: 81/56 mmHg) and hypoxemia. She was promptly transferred to the intensive care unit (ICU), where she required endotracheal intubation and initiation of mechanical ventilation. Laboratory investigations revealed marked leukocytosis (35 600/mm<sup>3</sup> with 83% neutrophils), severe hyperglycaemia (408 mg/dL) and pronounced lactic acidosis (8.8 mmol/L), prompting an initial working diagnosis of diabetic ketoacidosis.</p><p>However, this diagnosis was subsequently ruled out: urinary ketones were negative, viral serologies were non-reactive and laboratory parameters demonstrated elevated liver enzymes, lactate dehydrogenase (LDH), ultrasensitive troponin and creatine phosphokinase (CPK). Chest computed tomography revealed bilateral ground-glass opacities, predominantly affecting the right lung (<i>Figure</i> 1). Considering the initial lower limb pain, recent sting history and clinical evolution, severe scorpion envenomation was suspected, and specific antivenom [purified F (ab′)<sub>2</sub> polyclonal antibodies targeting <i>Tityus trivittatus</i>] were administered.</p><p>The patient developed signs of cardiogenic shock with low cardiac output, including cold extremities, oliguria, altered mental status, hypotension and tachycardia. Transthoracic Doppler echocardiography demonstrated severe global hypokinesis with an EF below 10% and a velocity-time integral of 7 cm measured at the left ventricular outflow tract; the left and right ventricles were of normal size; the LV showed akinesia of basal and mid-segments with preserved apical motion; diastolic function was pseudonormal; all cardiac valves were morphologically normal, as were atrial sizes and the pericardium; no signs of elevated pulmonary pressures were observed.. Pharmacologic support with norepinephrine and dobutamine was initiated. Despite these measures, the patient remained in a state of refractory hypoperfusion, with a delta CO<sub>2</sub> of 12, central venous oxygen saturation of 55%, persistent hyperlactataemia and haemodynamic parameters consistent with mixed shock (cardiac output: 2.17 L/min, cardiac index: 1.4 L/min/m<sup>2</sup>; pulmonary capillary wedge pressure: 32 mmHg; systemic vascular resistance: 400 dyn·s/cm<sup>5</sup>). Consequently, an intra-aortic balloon pump was inserted, followed by the initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for circulatory support.</p><p>Alternative aetiologies were thoroughly excluded: autoimmune and rheumatologic serologies were negative, blood cultures showed no microbial growth and the endocrine profile was within normal limits. Subsequently, a specimen of <i>Tityus trivittatus</i> was identified at the patient's residence, confirming the diagnosis (<i>Figure</i> 2).</p><p>The patient showed progressive clinical improvement, including a marked reduction in vasopressor and inotropic support, along with recovery of ventricular function on follow-up echocardiography (<i>Video</i> <i>S1</i>). VA-ECMO was successfully weaned after 50 h and 30 min of support (<i>Table</i> 1).</p><p>At 72 h, an extubation attempt was unsuccessful due to the development of acute respiratory distress syndrome, necessitating prone positioning, neuromuscular blockade and prolonged mechanical ventilation. The course was further complicated by ventilator-associated pneumonia, requiring tracheostomy and a total ICU stay of 31 days.</p><p>Following clinical stabilization, a comprehensive cardiac magnetic resonance imaging (MRI) study was performed. The MRI demonstrated preserved left ventricular EF (62%) with normal global and segmental wall motion. However, myocardial tissue characterization was abnormal. Quantitative mapping revealed elevated native T1 values (1285 ms), increased T2 relaxation times (70.8 ms) and a globally increased extracellular volume fraction (38%), all consistent with diffuse myocardial inflammation. In addition, T2-weighted STIR sequences showed increased signal intensity in the anterolateral wall, confirming the presence of myocardial oedema. Late gadolinium enhancement imaging revealed limited subepicardial enhancement in the mid-anterolateral and inferolateral segments, as well as at the inferior right ventricular insertion point. These findings fulfil the updated Lake Louise Criteria for acute non-ischaemic myocarditis (<i>Figure</i> 3).</p><p>Endomyocardial biopsy was initially considered, but we decided against it based on several clinical factors. The diagnosis of cardiogenic shock due to scorpion envenomation was strongly supported by the clinical context, including the temporal relationship with the sting, the absence of prior cardiac disease and cardiac MRI findings consistent with toxic myocarditis. There was no diagnostic uncertainty or suspicion of an alternative treatable cause such as giant cell or eosinophilic myocarditis, for which histological confirmation would have altered therapeutic management. Furthermore, the patient remained haemodynamically unstable during the critical phase, increasing the procedural risk.</p><p>After 16 additional days in the medical ward, the patient was discharged with no residual deficits except for mild critical illness myopathy, for which she was prescribed outpatient physiotherapy.</p><p>Cardiovascular involvement is one of the most critical and potentially fatal complications of scorpion envenomation, resulting either from direct myocardial toxicity or venom-induced myocarditis. Myocarditis in this context is primarily mediated by a massive release of catecholamines and vasoactive peptides triggered by neurotoxins acting on voltage-gated sodium and potassium channels, leading to excessive sympathetic and parasympathetic stimulation. The resulting catecholaminergic storm increases afterload, myocardial contractility and oxygen demand, contributing to myocardial ischaemia. Additionally, the venom may exert a direct cytotoxic effect on cardiomyocytes by disrupting intracellular ion homeostasis.<span><sup>6-8</sup></span></p><p>These pathophysiological mechanisms may lead to fulminant myocarditis with severe ventricular dysfunction, as observed in our patient. While this condition predominantly affects paediatric populations (98% of reported cases), our patient's low body mass index (19.53) may have contributed to increased venom toxicity and severity of clinical presentation. Her clinical findings—respiratory distress, tachycardia, pulmonary oedema and shock—are consistent with the most commonly reported manifestations in the literature.<span><sup>9</sup></span></p><p>The absence of clinical improvement following antivenom administration in this case can be attributed to several key factors. First, commercial antivenoms may have low immunoreactivity against the small molecular weight neurotoxins (3–15 kDa) that constitute the most clinically relevant components of the venom, particularly those affecting sodium and potassium channels.<span><sup>10, 11</sup></span> Furthermore, the efficacy of antivenom is highly time-dependent, and it is most effective when administered shortly after envenomation, before systemic complications develop. In our case, by the time of administration, the patient had already progressed to severe cardiogenic shock with established tissue injury. Together, these factors likely explain the poor clinical response to antivenom in this patient.<span><sup>12</sup></span></p><p>The management of severe cardiogenic shock requires an aggressive, multidisciplinary approach. In this case, despite optimal pharmacologic support, the patient's haemodynamic instability persisted, necessitating the use of advanced circulatory support with intra-aortic balloon pump and VA-ECMO. Mechanical support was instrumental in stabilizing her cardiopulmonary status and allowing time for myocardial recovery.</p><p>A notable strength of our approach was the early recognition of cardiogenic shock and the prompt initiation of ECMO, which likely contributed to the favourable outcome. Limitations include the rarity of this presentation in adults, which poses challenges for early diagnosis and delays in considering extracorporeal support in this context.</p><p>To our knowledge, this is the first reported case of VA-ECMO use in an adult patient with cardiogenic shock secondary to scorpion envenomation. While prior literature has described similar interventions in paediatric populations, there is a lack of documented evidence in adults. This case highlights the importance of considering ECMO in severe, refractory cardiovascular compromise due to scorpion venom, and it suggests that body size may influence disease severity.</p><p>This case highlights the potential for severe cardiovascular complications following <i>Tityus trivittatus</i> envenomation, even in adult patients. Fulminant myocarditis leading to refractory cardiogenic shock may require advanced circulatory support. The successful use of VA-ECMO in this patient illustrates that timely mechanical support can be lifesaving and facilitate complete myocardial recovery. Clinicians should maintain a high index of suspicion for cardiac involvement in scorpionism and consider ECMO as a therapeutic option in selected critically ill patients.</p><p>The patients have allowed personal data processing, and informed consent was obtained from all individual participants included in the study.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":11864,"journal":{"name":"ESC Heart Failure","volume":"12 5","pages":"3780-3784"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ehf2.15368","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ESC Heart Failure","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ehf2.15368","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

It is estimated that approximately 1.2 million scorpion stings occur globally each year. However, the true incidence is likely underestimated due to underreporting, particularly in endemic regions with limited access to healthcare systems. While the vast majority of stings result in only local symptoms, approximately 5% of patients develop systemic manifestations, and up to 1% progress to life-threatening complications such as acute heart failure, arrhythmias and cardiogenic shock.1

Scorpion envenomation represents a significant public health issue in tropical and subtropical regions, including parts of Latin America. This case occurred in Córdoba, Argentina, a temperate region in the central part of the country characterized by hot summers and mild winters. The city of Córdoba, where the patient was treated, is a large urban centre surrounded by hilly terrain and natural scorpion habitats. Tityus trivittatus, the most medically relevant scorpion species in Argentina, is endemic to the area, with increasing reports of envenomation during the warm season.2

Cardiovascular complications are among the most severe and life-threatening effects of systemic scorpion envenomation. In a systematic review of over 700 reported cases of scorpion-related myocarditis, pulmonary oedema occurred in approximately 60.7% of cases, and hypotension or cardiogenic shock in 45.8%. Sinus tachycardia was the most common ECG abnormality (82%), followed by ST-T changes (64.6%), with less frequent findings such as ventricular arrhythmias and atrioventricular blocks. Echocardiographic evaluations often reveal global or regional hypokinesia, ventricular dilation and reduced left ventricular ejection fraction (EF)—frequently below 40%. Right ventricular dysfunction and functional mitral or tricuspid regurgitation may also be observed. Despite the severity of these manifestations, many patients—particularly children—exhibit rapid and complete recovery with timely supportive care.3, 4

Although the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been documented in paediatric patients with severe envenomation, no previous cases have been reported in adults.5 We present what is, to our knowledge, the first documented case of successful VA-ECMO support in an adult patient with cardiogenic shock secondary to Tityus trivittatus envenomation, underscoring the importance of early recognition and aggressive intervention in such critical scenarios.

A 21 year-old female with no significant past medical history presented to the emergency department with acute onset of sharp pain in the right foot, radiating proximally along the lower limb, accompanied by sudden-onset vomiting. On admission, she was haemodynamically stable with normal vital signs. According to the patient and her family, the symptoms began approximately 4 h following a suspected scorpion sting to the right foot.

During the initial evaluation, the patient exhibited progressive clinical deterioration characterized by respiratory distress, tachypnoea (respiratory rate: 32 breaths/min), hypotension (blood pressure: 81/56 mmHg) and hypoxemia. She was promptly transferred to the intensive care unit (ICU), where she required endotracheal intubation and initiation of mechanical ventilation. Laboratory investigations revealed marked leukocytosis (35 600/mm3 with 83% neutrophils), severe hyperglycaemia (408 mg/dL) and pronounced lactic acidosis (8.8 mmol/L), prompting an initial working diagnosis of diabetic ketoacidosis.

However, this diagnosis was subsequently ruled out: urinary ketones were negative, viral serologies were non-reactive and laboratory parameters demonstrated elevated liver enzymes, lactate dehydrogenase (LDH), ultrasensitive troponin and creatine phosphokinase (CPK). Chest computed tomography revealed bilateral ground-glass opacities, predominantly affecting the right lung (Figure 1). Considering the initial lower limb pain, recent sting history and clinical evolution, severe scorpion envenomation was suspected, and specific antivenom [purified F (ab′)2 polyclonal antibodies targeting Tityus trivittatus] were administered.

The patient developed signs of cardiogenic shock with low cardiac output, including cold extremities, oliguria, altered mental status, hypotension and tachycardia. Transthoracic Doppler echocardiography demonstrated severe global hypokinesis with an EF below 10% and a velocity-time integral of 7 cm measured at the left ventricular outflow tract; the left and right ventricles were of normal size; the LV showed akinesia of basal and mid-segments with preserved apical motion; diastolic function was pseudonormal; all cardiac valves were morphologically normal, as were atrial sizes and the pericardium; no signs of elevated pulmonary pressures were observed.. Pharmacologic support with norepinephrine and dobutamine was initiated. Despite these measures, the patient remained in a state of refractory hypoperfusion, with a delta CO2 of 12, central venous oxygen saturation of 55%, persistent hyperlactataemia and haemodynamic parameters consistent with mixed shock (cardiac output: 2.17 L/min, cardiac index: 1.4 L/min/m2; pulmonary capillary wedge pressure: 32 mmHg; systemic vascular resistance: 400 dyn·s/cm5). Consequently, an intra-aortic balloon pump was inserted, followed by the initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for circulatory support.

Alternative aetiologies were thoroughly excluded: autoimmune and rheumatologic serologies were negative, blood cultures showed no microbial growth and the endocrine profile was within normal limits. Subsequently, a specimen of Tityus trivittatus was identified at the patient's residence, confirming the diagnosis (Figure 2).

The patient showed progressive clinical improvement, including a marked reduction in vasopressor and inotropic support, along with recovery of ventricular function on follow-up echocardiography (Video S1). VA-ECMO was successfully weaned after 50 h and 30 min of support (Table 1).

At 72 h, an extubation attempt was unsuccessful due to the development of acute respiratory distress syndrome, necessitating prone positioning, neuromuscular blockade and prolonged mechanical ventilation. The course was further complicated by ventilator-associated pneumonia, requiring tracheostomy and a total ICU stay of 31 days.

Following clinical stabilization, a comprehensive cardiac magnetic resonance imaging (MRI) study was performed. The MRI demonstrated preserved left ventricular EF (62%) with normal global and segmental wall motion. However, myocardial tissue characterization was abnormal. Quantitative mapping revealed elevated native T1 values (1285 ms), increased T2 relaxation times (70.8 ms) and a globally increased extracellular volume fraction (38%), all consistent with diffuse myocardial inflammation. In addition, T2-weighted STIR sequences showed increased signal intensity in the anterolateral wall, confirming the presence of myocardial oedema. Late gadolinium enhancement imaging revealed limited subepicardial enhancement in the mid-anterolateral and inferolateral segments, as well as at the inferior right ventricular insertion point. These findings fulfil the updated Lake Louise Criteria for acute non-ischaemic myocarditis (Figure 3).

Endomyocardial biopsy was initially considered, but we decided against it based on several clinical factors. The diagnosis of cardiogenic shock due to scorpion envenomation was strongly supported by the clinical context, including the temporal relationship with the sting, the absence of prior cardiac disease and cardiac MRI findings consistent with toxic myocarditis. There was no diagnostic uncertainty or suspicion of an alternative treatable cause such as giant cell or eosinophilic myocarditis, for which histological confirmation would have altered therapeutic management. Furthermore, the patient remained haemodynamically unstable during the critical phase, increasing the procedural risk.

After 16 additional days in the medical ward, the patient was discharged with no residual deficits except for mild critical illness myopathy, for which she was prescribed outpatient physiotherapy.

Cardiovascular involvement is one of the most critical and potentially fatal complications of scorpion envenomation, resulting either from direct myocardial toxicity or venom-induced myocarditis. Myocarditis in this context is primarily mediated by a massive release of catecholamines and vasoactive peptides triggered by neurotoxins acting on voltage-gated sodium and potassium channels, leading to excessive sympathetic and parasympathetic stimulation. The resulting catecholaminergic storm increases afterload, myocardial contractility and oxygen demand, contributing to myocardial ischaemia. Additionally, the venom may exert a direct cytotoxic effect on cardiomyocytes by disrupting intracellular ion homeostasis.6-8

These pathophysiological mechanisms may lead to fulminant myocarditis with severe ventricular dysfunction, as observed in our patient. While this condition predominantly affects paediatric populations (98% of reported cases), our patient's low body mass index (19.53) may have contributed to increased venom toxicity and severity of clinical presentation. Her clinical findings—respiratory distress, tachycardia, pulmonary oedema and shock—are consistent with the most commonly reported manifestations in the literature.9

The absence of clinical improvement following antivenom administration in this case can be attributed to several key factors. First, commercial antivenoms may have low immunoreactivity against the small molecular weight neurotoxins (3–15 kDa) that constitute the most clinically relevant components of the venom, particularly those affecting sodium and potassium channels.10, 11 Furthermore, the efficacy of antivenom is highly time-dependent, and it is most effective when administered shortly after envenomation, before systemic complications develop. In our case, by the time of administration, the patient had already progressed to severe cardiogenic shock with established tissue injury. Together, these factors likely explain the poor clinical response to antivenom in this patient.12

The management of severe cardiogenic shock requires an aggressive, multidisciplinary approach. In this case, despite optimal pharmacologic support, the patient's haemodynamic instability persisted, necessitating the use of advanced circulatory support with intra-aortic balloon pump and VA-ECMO. Mechanical support was instrumental in stabilizing her cardiopulmonary status and allowing time for myocardial recovery.

A notable strength of our approach was the early recognition of cardiogenic shock and the prompt initiation of ECMO, which likely contributed to the favourable outcome. Limitations include the rarity of this presentation in adults, which poses challenges for early diagnosis and delays in considering extracorporeal support in this context.

To our knowledge, this is the first reported case of VA-ECMO use in an adult patient with cardiogenic shock secondary to scorpion envenomation. While prior literature has described similar interventions in paediatric populations, there is a lack of documented evidence in adults. This case highlights the importance of considering ECMO in severe, refractory cardiovascular compromise due to scorpion venom, and it suggests that body size may influence disease severity.

This case highlights the potential for severe cardiovascular complications following Tityus trivittatus envenomation, even in adult patients. Fulminant myocarditis leading to refractory cardiogenic shock may require advanced circulatory support. The successful use of VA-ECMO in this patient illustrates that timely mechanical support can be lifesaving and facilitate complete myocardial recovery. Clinicians should maintain a high index of suspicion for cardiac involvement in scorpionism and consider ECMO as a therapeutic option in selected critically ill patients.

The patients have allowed personal data processing, and informed consent was obtained from all individual participants included in the study.

The authors declare no conflicts of interest.

Abstract Image

心源性休克需要VA-ECMO治疗蝎毒性心肌炎。
据估计,全球每年大约发生120万起蝎子蜇伤事件。然而,由于漏报,真实发病率可能被低估,特别是在获得卫生保健系统的机会有限的流行地区。虽然绝大多数蜇伤仅导致局部症状,但约5%的患者会出现全身性症状,高达1%的患者会发展为危及生命的并发症,如急性心力衰竭、心律失常和心源性休克。蝎子中毒是热带和亚热带地区,包括拉丁美洲部分地区的一个重大公共卫生问题。该病例发生在阿根廷Córdoba,这是该国中部的温带地区,夏季炎热,冬季温和。患者接受治疗的城市Córdoba是一个被丘陵地形和天然蝎子栖息地包围的大型城市中心。Tityus trivittatus是阿根廷最具医学意义的蝎子物种,是该地区的特有物种,在温暖季节,越来越多的报告显示有毒。心血管并发症是全身蝎子中毒最严重和危及生命的后果之一。在一项对700多例蝎子相关心肌炎病例的系统回顾中,大约60.7%的病例发生肺水肿,45.8%的病例发生低血压或心源性休克。窦性心动过速是最常见的心电图异常(82%),其次是ST-T改变(64.6%),室性心律失常和房室传导阻滞等少见的表现。超声心动图评价经常显示整体或局部运动不足,心室扩张和左心室射血分数(EF)降低-经常低于40%。右室功能障碍和二尖瓣或三尖瓣功能反流也可观察到。尽管这些症状很严重,但许多患者,特别是儿童,在及时的支持性护理下表现出迅速和完全的恢复。尽管静脉-动脉体外膜氧合(VA-ECMO)在严重中毒的儿科患者中的应用已有文献记载,但在成人中尚无此类病例的报道我们提出,据我们所知,第一个成功的VA-ECMO支持的成人心脏源性休克患者继发于三vitatus中毒,强调早期识别和积极干预的重要性在这种危急情况下。21岁女性,无明显既往病史,因右脚急性起刺痛,沿下肢近端放射,并伴有突发性呕吐而就诊于急诊科。入院时,患者血流动力学稳定,生命体征正常。据患者及其家属说,症状开始于疑似蝎子蜇伤右脚后约4小时。在初步评估时,患者表现出以呼吸窘迫、呼吸急促(呼吸频率:32次/分钟)、低血压(血压:81/56 mmHg)和低氧血症为特征的进行性临床恶化。她立即被转移到重症监护室(ICU),在那里她需要气管插管并开始机械通气。实验室检查显示明显的白细胞增多(35 600/mm3,中性粒细胞83%),严重的高血糖(408 mg/dL)和明显的乳酸酸中毒(8.8 mmol/L),提示初步诊断为糖尿病酮症酸中毒。然而,这一诊断随后被排除:尿酮呈阴性,病毒血清学无反应,实验室参数显示肝酶、乳酸脱氢酶(LDH)、超敏感肌钙蛋白和肌酸磷酸激酶(CPK)升高。胸部计算机断层扫描显示双侧磨玻璃影,主要影响右肺(图1)。考虑到患者最初的下肢疼痛、近期蜇伤史和临床演变,怀疑严重蝎子中毒,给予特异性抗蛇毒血清[针对Tityus trivittatus的纯化F (ab’)2多克隆抗体]。患者出现心源性休克伴低心输出量的体征,包括四肢冰冷、尿少、精神状态改变、低血压和心动过速。经胸多普勒超声心动图显示严重的全身运动不足,EF低于10%,左心室流出道测量的速度-时间积分为7cm;左、右心室大小正常;左心室基底和中节运动减弱,顶端运动保持不变;舒张功能假正常;所有心脏瓣膜形态正常,心房大小和心包膜形态正常;未观察到肺动脉压升高的迹象。开始了去甲肾上腺素和多巴酚丁胺的药物支持。 尽管采取了这些措施,患者仍处于难治性低灌注状态,δ CO2为12,中心静脉氧饱和度为55%,持续高乳酸血症,血流动力学参数与混合性休克一致(心输出量:2.17 L/min,心脏指数:1.4 L/min/m2,肺毛细血管楔压:32 mmHg,全身血管阻力:400 dyn·s/cm5)。因此,插入主动脉内球囊泵,随后启动静脉-动脉体外膜氧合(VA-ECMO)以支持循环。其他病因被彻底排除:自身免疫和风湿病血清学阴性,血液培养显示没有微生物生长,内分泌谱在正常范围内。随后,在患者住所鉴定了三头提鼠标本,证实了诊断(图2)。患者表现出渐进式临床改善,包括血管加压剂和肌力支持明显减少,以及随访超声心动图(视频S1)心室功能恢复。VA-ECMO在支持50小时30分钟后成功脱机(表1)。72 h时,由于急性呼吸窘迫综合征的发生,拔管尝试失败,需要俯卧位、神经肌肉封锁和延长机械通气时间。该过程因呼吸机相关性肺炎进一步复杂化,需要气管切开术,ICU总住院31天。临床稳定后,进行了全面的心脏磁共振成像(MRI)研究。MRI显示左心室EF保留(62%),整体和节段性壁运动正常。然而,心肌组织特征异常。定量图谱显示T1升高(1285 ms), T2松弛时间增加(70.8 ms),细胞外体积分数增加(38%),所有这些都与弥漫性心肌炎症一致。此外,t2加权STIR序列显示前外壁信号强度增加,证实心肌水肿的存在。晚期钆增强显像显示心外膜下有限的增强在中间前外侧和内外侧段,以及在右室下插入点。这些结果符合最新的路易斯湖急性非缺血性心肌炎标准(图3)。我们最初考虑过心内膜活检,但基于几个临床因素,我们决定放弃。由于蝎子中毒引起的心源性休克的诊断得到了临床背景的有力支持,包括与蜇伤的时间关系,既往无心脏疾病以及心脏MRI结果与中毒性心肌炎一致。没有诊断不确定性或怀疑其他可治疗的原因,如巨细胞或嗜酸性心肌炎,组织学证实将改变治疗管理。此外,患者在关键阶段血流动力学不稳定,增加了手术风险。在病房多住了16天后,患者出院,除了轻度危重性肌病外,没有任何残留缺陷,为此她接受了门诊物理治疗。心血管受累是蝎子中毒最严重和潜在致命的并发症之一,可由直接的心肌毒性或毒蛇引起的心肌炎引起。在这种情况下,心肌炎主要是由作用于电压门控钠和钾通道的神经毒素引发儿茶酚胺和血管活性肽的大量释放介导的,导致过度的交感神经和副交感神经刺激。由此产生的儿茶酚胺能风暴增加后负荷、心肌收缩力和需氧量,导致心肌缺血。此外,毒液可能通过破坏细胞内离子稳态对心肌细胞产生直接的细胞毒性作用。这些病理生理机制可能导致暴发性心肌炎并伴有严重的心室功能障碍,正如本例患者所观察到的那样。虽然这种情况主要影响儿科人群(98%的报告病例),但该患者的低体重指数(19.53)可能导致了毒液毒性的增加和临床表现的严重程度。她的临床表现——呼吸窘迫、心动过速、肺水肿和休克——与文献中最常报道的表现一致。在这种情况下,抗蛇毒血清治疗后没有临床改善可归因于几个关键因素。首先,商业抗蛇毒血清对小分子量神经毒素(3-15 kDa)的免疫反应性可能较低,而这些神经毒素是蛇毒临床最相关的成分,特别是那些影响钠和钾通道的成分。 10,11此外,抗蛇毒血清的疗效是高度时间依赖性的,在中毒后不久,在出现全身并发症之前给药是最有效的。在我们的病例中,在给药时,患者已经发展为严重的心源性休克,并伴有组织损伤。总之,这些因素可能解释了该患者抗蛇毒血清的不良临床反应。严重心源性休克的治疗需要积极的、多学科的方法。在这种情况下,尽管有最佳的药物支持,患者的血流动力学不稳定持续存在,需要使用先进的循环支持与主动脉内球囊泵和VA-ECMO。机械支持有助于稳定她的心肺状态,并为心肌恢复留出时间。我们的方法的一个显著优势是早期识别心源性休克和迅速启动ECMO,这可能有助于良好的结果。局限性包括这种表现在成人中的罕见性,这对早期诊断和在考虑体外支持时的延迟提出了挑战。据我们所知,这是首次报道VA-ECMO用于蝎子中毒继发心源性休克的成人患者。虽然先前的文献描述了在儿科人群中类似的干预措施,但在成人中缺乏书面证据。该病例强调了在蝎子毒液引起的严重、难固性心血管损害中考虑ECMO的重要性,并提示体型可能影响疾病的严重程度。本病例强调了三头提鱼中毒后严重心血管并发症的可能性,即使在成人患者中也是如此。暴发性心肌炎导致难治性心源性休克可能需要先进的循环支持。该患者成功使用VA-ECMO说明及时的机械支持可以挽救生命并促进心肌完全恢复。临床医生应保持对蝎子病心脏受累的高度怀疑,并考虑将ECMO作为选择的危重患者的治疗选择。患者允许处理个人数据,并获得了研究中所有个体参与者的知情同意。作者声明无利益冲突。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ESC Heart Failure
ESC Heart Failure Medicine-Cardiology and Cardiovascular Medicine
CiteScore
7.00
自引率
7.90%
发文量
461
审稿时长
12 weeks
期刊介绍: ESC Heart Failure is the open access journal of the Heart Failure Association of the European Society of Cardiology dedicated to the advancement of knowledge in the field of heart failure. The journal aims to improve the understanding, prevention, investigation and treatment of heart failure. Molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, as well as the clinical, social and population sciences all form part of the discipline that is heart failure. Accordingly, submission of manuscripts on basic, translational, clinical and population sciences is invited. Original contributions on nursing, care of the elderly, primary care, health economics and other specialist fields related to heart failure are also welcome, as are case reports that highlight interesting aspects of heart failure care and treatment.
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