Simplification of the oral sodium loading test: 2-day method replacing 3-day method.

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-07-01 DOI:10.1016/j.eprac.2025.06.021

Zewen Li, Jian Zhong, Yunying Cui, Songlin Yu, Ling Qiu, Anli Tong

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引用次数: 0

Abstract

Objectives: As one of the diagnostic tests for primary aldosteronism (PA), the oral sodium loading test (OSLT) usually takes 3 days, which is time-consuming.This study aims to investigate the possibility of the 2-day method replacing the 3-day method in the OSLT.

Methods: In this prospective study, both PA patients and healthy participants were recruited and underwent an oral high-sodium diet for 3 consecutive days from December 2023 to December 2024. Daily fasting blood and 24h urine samples were collected before, on the second day, and on the third day of the OSLT.

Results: 12 PA patients [median age of 51.5 (42.0∼57.0) years, 75% men] and 12 healthy participants [median age of 30.5(24.0-39.8)years, 25% men] were recruited in this study. After oral sodium loading, all participants had a 24h urinary sodium> 200 mmol/24h. 24h urinary aldosterone (UALD) was not significantly different between the second day and the third day in PA patients [18.24 (15.58∼33.83) vs. 17.25 (12.74∼27.06) μg/24h, P=0.583], as well as in healthy participants [2.65 (1.67∼3.82) vs. 2.63 (1.63∼4.34) μg/24h, P=0.747]. There was a strong correlation of 24h UALD on the second day and the third day in both PA patients and healthy participants (r=0.8322 and 0.9333, respectively). Aldosterone-related steroid hormone profile showed no statistically significant difference between the two days, either for PA patients or for healthy participants.

Conclusions: This study confirms that the 2-day method can replace the 3-day method in OSLT for a more convenient diagnosis of PA.

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简化口服钠负荷试验：2天法代替3天法。

目的：作为原发性醛固酮增多症（PA）的诊断试验之一，口服钠负荷试验（OSLT）通常需要3天，耗时较长。本研究旨在探讨在OSLT中2天法取代3天法的可能性。方法：在这项前瞻性研究中，招募PA患者和健康参与者，并于2023年12月至2024年12月连续3天口服高钠饮食。在OSLT开始前、第二天和第三天采集每日空腹血和24小时尿样。结果：本研究招募了12名PA患者[中位年龄为51.5（42.0 ~ 57.0）岁，75%为男性]和12名健康受试者[中位年龄为30.5（24.0 ~ 39.8）岁，25%为男性]。口服钠负荷后，所有参与者24小时尿钠浓度为200 mmol/24小时。PA患者24小时尿醛固酮（UALD）在第2天和第3天之间无显著差异[18.24 (15.58 ~ 33.83)vs. 17.25 (12.74 ~ 27.06) μg/24h， P=0.583]，健康参与者[2.65 (1.67 ~ 3.82)vs. 2.63 (1.63 ~ 4.34) μg/24h， P=0.747]。PA患者与健康受试者在第2天、第3天的24h UALD有很强的相关性（r分别为0.8322、0.9333）。醛固酮相关类固醇激素谱在两天之间没有统计学上的显著差异，无论是对于PA患者还是健康参与者。结论：本研究证实，在OSLT中，2天法可以取代3天法，更方便地诊断PA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.