Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management.

IF 16.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation research Pub Date : 2025-07-07 Epub Date: 2025-07-03 DOI:10.1161/CIRCRESAHA.125.325531

Vinayak Subramanian, Wesley J Tucker, Anthony E Peters, Bharathi Upadhya, Dalane W Kitzman, Ambarish Pandey

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引用次数: 0

Abstract

A demographic shift toward an aging population is occurring worldwide. Commensurate with this trend, age-related diseases are also rising. Although aging is an immutable part of life, biological aging is a highly heterogeneous process influenced by health-related behaviors, genetics, and the environment. The biological effects of aging are evident across all organ systems. Some individuals demonstrate an accelerated aging phenotype, which is associated with substantial morbidity and mortality. Moreover, common cardiovascular conditions, such as heart failure with preserved ejection fraction, can be conceptualized as a consequence of accelerated aging. Physical activity and exercise training modify the biological effects of accelerated aging considerably. They are associated with various salutary benefits and have emerged as potent therapeutics in disease states characterized by the accelerated aging phenotype. In this state-of-the-art review, we discuss the age-related changes observed in cardiovascular and peripheral tissues, the implications of age acceleration, and the effectiveness and mechanisms of physical activity and exercise training to curb the deleterious effects of aging and improve outcomes.

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心血管老化和运动：对心力衰竭预防和管理的影响。

人口结构向老龄化的转变正在全球范围内发生。与这一趋势相称的是，与年龄有关的疾病也在增加。尽管衰老是生命不可改变的一部分，但生物衰老是一个高度异质性的过程，受健康相关行为、遗传和环境的影响。衰老的生物学效应在所有器官系统中都很明显。有些人表现出加速衰老的表型，这与大量的发病率和死亡率有关。此外，常见的心血管疾病，如射血分数保持不变的心力衰竭，可以被认为是加速衰老的结果。体育活动和运动训练显著地改变了加速衰老的生物学效应。它们具有各种有益的益处，并已成为以加速衰老表型为特征的疾病状态的有效治疗方法。在这篇最新的综述中，我们讨论了在心血管和外周组织中观察到的与年龄相关的变化，年龄加速的含义，以及体育活动和运动训练在抑制衰老有害影响和改善预后方面的有效性和机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation research 医学-外周血管病

CiteScore

29.60

自引率

2.00%

发文量

535

审稿时长

3-6 weeks

期刊介绍： Circulation Research is a peer-reviewed journal that serves as a forum for the highest quality research in basic cardiovascular biology. The journal publishes studies that utilize state-of-the-art approaches to investigate mechanisms of human disease, as well as translational and clinical research that provide fundamental insights into the basis of disease and the mechanism of therapies. Circulation Research has a broad audience that includes clinical and academic cardiologists, basic cardiovascular scientists, physiologists, cellular and molecular biologists, and cardiovascular pharmacologists. The journal aims to advance the understanding of cardiovascular biology and disease by disseminating cutting-edge research to these diverse communities. In terms of indexing, Circulation Research is included in several prominent scientific databases, including BIOSIS, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, and MEDLINE. This ensures that the journal's articles are easily discoverable and accessible to researchers in the field. Overall, Circulation Research is a reputable publication that attracts high-quality research and provides a platform for the dissemination of important findings in basic cardiovascular biology and its translational and clinical applications.