Exploring the bioactivity of synovial fluid in osteoarthritis: implications for disease understanding and management.

IF 2.8 4区 医学 Q3 CELL BIOLOGY
Keanu Hh Haenen, Guus Gh van den Akker, Marjolein Mj Caron, Tonia L Vincent, Tim Jm Welting
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引用次数: 0

Abstract

Osteoarthritis is a whole-joint disease. While some intra-articular tissues are in physical contact with each other, it is the synovial fluid that acts as a major connecting medium into which joint tissues and cells release their bioactive molecular content. Osteoarthritic synovial fluid contains a plethora of systemic and locally derived biomolecular factors, including cells, extracellular vesicles, proteins, crystals, metabolites, and RNAs. While many of these biomolecular factors are primarily considered as potential biomarkers for OA diagnostics, the bioactivity relayed by these factors and their critical contributions to osteoarthritis pathobiology have received less attention. In this review, we highlight insights into the bioactivity of molecular constituents contained within human osteoarthritic synovial fluid, its intrinsic bioactivity, as well as its potential, and the barriers to use synovial fluid to biomolecularly stratify individuals for specific targeted therapies or osteoarthritis stage.

探讨骨关节炎滑膜液的生物活性:对疾病理解和管理的意义。
骨关节炎是一种全关节疾病。虽然一些关节内组织彼此物理接触,但滑膜液是关节组织和细胞释放其生物活性分子含量的主要连接介质。骨关节炎滑膜液含有大量系统性和局部来源的生物分子因子,包括细胞、细胞外囊泡、蛋白质、晶体、代谢物和rna。虽然许多这些生物分子因子主要被认为是OA诊断的潜在生物标志物,但这些因子所传递的生物活性及其对骨关节炎病理生物学的重要贡献却很少受到关注。在这篇综述中,我们重点介绍了人类骨关节炎滑膜液中分子成分的生物活性,其内在生物活性及其潜力,以及使用滑膜液对个体进行特定靶向治疗或骨关节炎阶段的生物分子分层的障碍。
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来源期刊
Connective Tissue Research
Connective Tissue Research 生物-细胞生物学
CiteScore
6.60
自引率
3.40%
发文量
37
审稿时长
2 months
期刊介绍: The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.
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