Keanu Hh Haenen, Guus Gh van den Akker, Marjolein Mj Caron, Tonia L Vincent, Tim Jm Welting
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引用次数: 0
Abstract
Osteoarthritis is a whole-joint disease. While some intra-articular tissues are in physical contact with each other, it is the synovial fluid that acts as a major connecting medium into which joint tissues and cells release their bioactive molecular content. Osteoarthritic synovial fluid contains a plethora of systemic and locally derived biomolecular factors, including cells, extracellular vesicles, proteins, crystals, metabolites, and RNAs. While many of these biomolecular factors are primarily considered as potential biomarkers for OA diagnostics, the bioactivity relayed by these factors and their critical contributions to osteoarthritis pathobiology have received less attention. In this review, we highlight insights into the bioactivity of molecular constituents contained within human osteoarthritic synovial fluid, its intrinsic bioactivity, as well as its potential, and the barriers to use synovial fluid to biomolecularly stratify individuals for specific targeted therapies or osteoarthritis stage.
期刊介绍:
The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology.
The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented.
The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including
Biochemistry
Cell and Molecular Biology
Immunology
Structural Biology
Biophysics
Biomechanics
Regenerative Medicine
The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.