{"title":"MFG-E8 in Microglial Regulation: A Review of Basic Research in the Central Nervous System","authors":"Dan Li, Weihong Lu, Rongchun Wang, Ying Ma","doi":"10.1111/1750-3841.70235","DOIUrl":null,"url":null,"abstract":"<p>Microglia are resident immune cells of the central nervous system (CNS) that play important roles under both physiological and pathological conditions. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a glycoprotein that regulates various microglial functions and has a crucial impact on CNS health and disease. MFG-E8 promotes phagocytosis and anti-inflammatory responses and inhibits oxidative stress in microglia, thereby exerting neuroprotective effects and reducing neuroinflammation in diseases such as Alzheimer's and Parkinson's disease. Additionally, it promotes neural regeneration by stimulating the neurogenesis of neural progenitor cells and enhancing tissue repair. However, MFG-E8 may also regulate microglia to exert pro-tumor effects, facilitating CNS tumor invasion and making it a potential therapeutic target. This review focuses on targeting MFG-E8 to regulate microglial function and provides a basis for identifying therapeutic targets for CNS diseases in the future.</p>","PeriodicalId":193,"journal":{"name":"Journal of Food Science","volume":"90 7","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1750-3841.70235","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Food Science","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1750-3841.70235","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Microglia are resident immune cells of the central nervous system (CNS) that play important roles under both physiological and pathological conditions. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a glycoprotein that regulates various microglial functions and has a crucial impact on CNS health and disease. MFG-E8 promotes phagocytosis and anti-inflammatory responses and inhibits oxidative stress in microglia, thereby exerting neuroprotective effects and reducing neuroinflammation in diseases such as Alzheimer's and Parkinson's disease. Additionally, it promotes neural regeneration by stimulating the neurogenesis of neural progenitor cells and enhancing tissue repair. However, MFG-E8 may also regulate microglia to exert pro-tumor effects, facilitating CNS tumor invasion and making it a potential therapeutic target. This review focuses on targeting MFG-E8 to regulate microglial function and provides a basis for identifying therapeutic targets for CNS diseases in the future.
期刊介绍:
The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science.
The range of topics covered in the journal include:
-Concise Reviews and Hypotheses in Food Science
-New Horizons in Food Research
-Integrated Food Science
-Food Chemistry
-Food Engineering, Materials Science, and Nanotechnology
-Food Microbiology and Safety
-Sensory and Consumer Sciences
-Health, Nutrition, and Food
-Toxicology and Chemical Food Safety
The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.