The influence of the choroid plexus on brain function: beyond its role in cerebrospinal fluid production.

Sayako Katada, Kelren S Rodrigues, Kinichi Nakashima
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引用次数: 0

Abstract

The choroid plexus (ChP) is a highly vascularized tissue located within the brain ventricles. Traditionally recognized for its primary role in cerebrospinal fluid (CSF) production, recent research has unveiled a far more complex and dynamic picture of the ChP's contributions to brain health and homeostasis. The ChP is composed of tight-junction-bound epithelial cells and the underlying stroma-rich fenestrated capillaries of blood vessels. This unique architecture creates a barrier between the peripheral blood and CSF, regulating the brain's internal environment. The discovery that CSF enters the brain parenchyma via the perivascular space, coupled with the identification of a functional brain lymphatic system linked to CSF turnover, further highlights the ChP as a gatekeeper of waste clearance and fluid homeostasis. This review will cover the development and histology of ChP, focusing on the dynamic response of the blood-CSF barrier in the context of systemic inflammation, a process whose molecular mechanisms have recently been elucidated.

脉络膜丛对脑功能的影响:超越其在脑脊液产生中的作用。
脉络膜丛(ChP)是位于脑室内的一个高度血管化的组织。传统上认为其主要作用是在脑脊液(CSF)的产生中,最近的研究揭示了ChP对脑健康和体内平衡的贡献更为复杂和动态的图景。ChP由紧密结合的上皮细胞和下层富含基质的开孔毛细血管组成。这种独特的结构在外周血和脑脊液之间形成屏障,调节大脑的内部环境。脑脊液通过血管周围间隙进入脑实质的发现,加上与脑脊液转换相关的功能性脑淋巴系统的鉴定,进一步强调了ChP作为废物清除和流体稳态的看门人。这篇综述将涵盖ChP的发展和组织学,重点关注全身炎症背景下血- csf屏障的动态反应,这一过程的分子机制最近已被阐明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
11.00
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