Quantification of normal skin thickness using very high-frequency ultrasound: a clinical study in Chinese adults.

IF 2.9 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yongrui Wang, Mei Tian, Ruiqian Guo, Fangxue Du, Li Qiu, Yuanjiao Tang
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引用次数: 0

Abstract

Background: Measurement of skin thickness provides an objective basis for diagnosing skin diseases and evaluating treatment efficacy. High-frequency ultrasound (HFUS) offers the advantages of high frequency and resolution, enabling clear visualization of the epidermis, dermis. Very high-frequency ultrasound (VHFUS) boasts an even higher frequency and resolution, allowing for more precise imaging of each skin layer. Both ultrasonic probes with different frequencies can accurately measure skin thickness. The purpose of this study was to compare the differences in skin thickness measured by the above ultrasonic probes in healthy Chinese adults and to analyze the factors influencing skin thickness.

Methods: A total of 74 healthy volunteers were included in this cross-sectional study. VHFUS (50 MHz) and HFUS (20 MHz) were used to obtain normal sonographic images of the skin, and the epidermal, dermal, and full-thickness skin thicknesses were measured. We compared the differences in skin thickness measurements between probes of different frequencies, and the differences in VHFUS skin thickness measurements in different sections, left and right sides, sexes, and different parts, and analyzed the relationship between skin thickness measurements and age and body mass index (BMI).

Results: The differences between the epidermal layers of the abdomen (0.1100±0.0178, 0.1097±0.0156 mm; 0.1176±0.0159, 0.1159±0.0158 mm) and chest (0.1039±0.0189, 0.1038±0.0171 mm; 0.1102±0.0169, 0.1134±0.0159 mm) in the longitudinal and transverse sections observed using VHFUS and HFUS were statistically significant (P=0.007, 0.018, 0.034, 0.001). Right and left comparisons of the dermal and full-thickness skin thickness measurements of the forearm (dermal: 1.6138±0.4217, 1.5696±0.3900 mm; full-thickness skin: 1.7324±0.4311, 1.6772±0.3898 mm), and leg (dermal: 1.7977±0.4987, 1.7164±0.4342 mm; full-thickness skin: 1.8964±0.4827, 1.8336±0.4330 mm) show statistically significant differences. Sex comparisons indicated differences in the dermal and full-thickness skin measurements in certain areas (P<0.05). Furthermore, the epidermal layer of the right foot dorsum, dermal layer, and overall skin thickness of the right calf were negatively correlated with age (r=-0.245, -0.229, -0.257). Some dermal and full-thickness skin measurements exhibited weak positive correlations with BMI (r=0.302, 0.306, 0.313, 0.314, 0.300, 0.291, 0.299, 0.302, 0.263, 0.262, 0.255, 0.257). Significant differences in the thicknesses of the skin were observed across various anatomical regions (P<0.05).

Conclusions: VHFUS can obtain clear skin sonograms and accurately measure skin thickness, particularly epidermal thickness. For sites where there is no significant difference in skin thickness between the two sides, the contralateral side can be selected as a reference for unilateral lesions, and age, BMI, and sex impact skin thickness measurement. Different parts of the skin have different thicknesses. Therefore, when measuring skin thickness, it is necessary to establish a corresponding reference range for normal skin thickness based on these influencing factors.

用甚高频超声定量测定正常皮肤厚度:中国成人的临床研究。
背景:皮肤厚度的测量为皮肤病的诊断和治疗效果的评价提供了客观依据。高频超声(HFUS)具有高频率和高分辨率的优点,能够清晰地显示表皮、真皮层。甚高频超声(VHFUS)拥有更高的频率和分辨率,可以更精确地成像每一层皮肤。两种不同频率的超声探头均能准确测量皮肤厚度。本研究的目的是比较上述超声探头测量的中国健康成年人皮肤厚度的差异,并分析影响皮肤厚度的因素。方法:对74名健康志愿者进行横断面研究。使用VHFUS (50 MHz)和HFUS (20 MHz)获得皮肤的正常超声图像,并测量表皮、真皮层和全层皮肤厚度。比较不同频率探针间皮肤厚度测量值的差异,以及VHFUS不同断面、左右两侧、性别、不同部位皮肤厚度测量值的差异,并分析皮肤厚度测量值与年龄、身体质量指数(BMI)的关系。结果:腹部表皮层差异(0.1100±0.0178 mm, 0.1097±0.0156 mm;0.1176±0.0159,0.1159±0.0158 mm)和胸部(0.1039±0.0189,0.1038±0.0171 mm;分别为0.1102±0.0169、0.1134±0.0159 mm,差异有统计学意义(P=0.007、0.018、0.034、0.001)。左、右比较前臂真皮与全层皮肤厚度测量值(真皮:1.6138±0.4217,1.5696±0.3900 mm;全层皮肤:1.7324±0.4311,1.6772±0.3898 mm),腿部(真皮:1.7977±0.4987,1.7164±0.4342 mm;全层皮肤:1.8964±0.4827、1.8336±0.4330 mm)差异有统计学意义。结论:VHFUS可以获得清晰的皮肤声像图,准确测量皮肤厚度,尤其是表皮厚度。对于两侧皮肤厚度无明显差异的部位,可选择对侧作为单侧病变的参照,年龄、BMI、性别影响皮肤厚度测量。皮肤的不同部位厚度不同。因此,在测量皮肤厚度时,有必要根据这些影响因素建立相应的正常皮肤厚度参考范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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